ZFIN Figure: Essers et al., 2015, Fig. 4

ZFIN ID: ZDB-FIG-190627-3

ZFIN ID: ZDB-FIG-190627-3

Essers et al., 2015 - The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2. Oncogene 146(3):789-800.e8 Full text @ Oncogene

ADDITIONAL FIGURES

EXPRESSION / LABELING:

Genes:	birc2 birc5a cflara
Fish:	WT vhl^{hu2117/hu2117}
Condition:	gamma ray
Anatomical Term:	whole organism
Stage:	Day 5

PHENOTYPE:

Fish:	WT vhl^{hu2117/hu2117}
Condition:	gamma ray
Observed In:	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest regulation of cell cycle whole organism
Stage:	Day 5

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details

Gene	Fish	Conditions	Stage	Anatomy	Assay
birc2	WT	control	Day 5	whole organism	RTPCR
	WT	gamma ray	Day 5	whole organism	RTPCR
	vhl^{hu2117/hu2117}	control	Day 5	whole organism	RTPCR
	vhl^{hu2117/hu2117}	gamma ray	Day 5	whole organism	RTPCR
birc5a	WT	control	Day 5	whole organism	RTPCR
	WT	gamma ray	Day 5	whole organism	RTPCR
	vhl^{hu2117/hu2117}	control	Day 5	whole organism	RTPCR
	vhl^{hu2117/hu2117}	gamma ray	Day 5	whole organism	RTPCR
cflara	WT	control	Day 5	whole organism	RTPCR
	WT	gamma ray	Day 5	whole organism	RTPCR
	vhl^{hu2117/hu2117}	control	Day 5	whole organism	RTPCR
	vhl^{hu2117/hu2117}	gamma ray	Day 5	whole organism	RTPCR

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
WT	gamma ray	Day 5	whole organism birc5a expression decreased amount, abnormal
vhl^{hu2117/hu2117}	control	Day 5	whole organism birc5a expression increased amount, abnormal
vhl^{hu2117/hu2117}	gamma ray	Day 5	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest decreased process quality, abnormal
		Day 5	regulation of cell cycle decreased process quality, abnormal

Full text @ Oncogene