FIGURE

Fig. 5

ID

ZDB-FIG-181121-5

Publication

Sanchez et al., 2018 - Quinoxaline protects zebrafish lateral line hair cells from cisplatin and aminoglycosides damage

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Fig. 5

Qx partially protects against acute exposure to neomycin. 5dpf larvae were treated for 30 min with neomycin (Neo) 50 μM-400 μM (A,C,E,G) or for 8 hours with Qx 300 μM and Neo was added 30 min before the end of the incubation time (B,D,F,H). Untreated or Qx-treated animals were used as controls. Animals were fixed, stained for otoferlin (red) and phalloidin (green) and analyzed by confocal microscopy. (I) Quantification of the number of hair cells per neuromast after the different treatments represented as mean +/− SEM. One-way ANOVA, Dunnett post test. *p < 0.05, **p < 0.01, ***p < 0.001. Black asterisks compared versus control. Red asterisk compared versus the corresponding Neo-only treatment. (J) Scores for neuromast morphology. Scale bar: 6 μm. Data were taken from at least 20 animals and 3 experiments runs.

Expression Data

Antibody:	Ab1-otof
Fish:	AB
Conditions:	chemical treatment by environment: neomycin chemical treatment by environment: neomycin
Anatomical Term:	neuromast hair cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by environment: neomycin chemical treatment by environment: neomycin
Observed In:	neuromast neuromast hair cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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