FIGURE

Fig. 3

ID

ZDB-FIG-180827-79

Publication

Tseng et al., 2018 - Modeling Niemann-Pick disease type C1 in zebrafish: a robust platform for in vivo screening of candidate therapeutic compounds.

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Fig. 3

Histopathology of adult npc1^m/m liver and brain tissue. (A,B) Photographs of Hematoxylin and Eosin (H&E)-stained hindbrain tissue sections from adult npc1^+/+ (A) and npc1^m/m (B) zebrafish at 9 weeks of age. Axonal spheroids are indicated by the arrowheads. Scale bar: 50 μm. (C,D) H&E-stained cerebellar sections from 9-week npc1^+/+ (C) and npc1^m/m (D) zebrafish. The arrows indicate cerebellar Purkinje neurons. Scale bar: 100 μm. (E,F) H&E-stained liver sections from 9-week npc1^+/+ (E) and npc1^m/m (F) zebrafish. Scale bar: 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	npc1^hg37/hg37
Observed In:	hepatocyte hindbrain axon Purkinje cell
Stage:	Days 45-89

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.