FIGURE

Fig. 2

ID

ZDB-FIG-180807-26

Publication

Sztal et al., 2018 - Testing of therapies in a novel nebulin nemaline myopathy model demonstrate a lack of efficacy

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Fig. 2

Characterisation of skeletal muscle pathology in neb^−/− fish. a Gomori trichome staining of neb^−/− skeletal muscle sections reveal the presence of dark regions (arrows) throughout the muscle indicative of nemaline bodies not observed in neb^+/+ fish. Nuclei (arrowhead) are evenly organized in neb^+/+, however, appear disorganized in neb^−/− fish. b Quantification of normalized fiber area from Gomori trichome stained sections in neb^−/− (n = 23 fibers) compared to neb^+/+ fish (n = 21 fibers). Error bars represent mean±SD, *** p < 0.001. c neb^−/− mutants exhibit F-actin (red) and Actinin2 (green) positive aggregates at the myosepta (arrowheads) (and zoomed inset) compared to wildtype siblings at 2 dpf

Expression Data

Antibody:	Ab1-actn
Fish:	neb^sa906/sa906
Anatomical Terms:	skeletal muscle skeletal muscle vertical myoseptum
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	neb^sa906/sa906
Observed In:	skeletal muscle skeletal muscle vertical myoseptum skeletal muscle cell
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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