FIGURE
Fig. 5
- ID
- ZDB-FIG-180725-9
- Publication
- Ni et al., 2018 - A noncanonical function of histidyl-tRNA synthetase: inhibition of vascular hyperbranching during zebrafish development
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Fig. 5
The role of Hars in regulating vascular development is functionally conserved between zebrafish and humans. (A) Hars protein sequence alignment shows high homology between the three species tested. (B,C) Injection of human HARS mRNA rescues ectopic brain vascular branching in zebrafish hars−/−, indicating a conserved regulatory function of Hars in vascular development between zebrafish and humans. (D) Confocal immunofluorescence microscopy shows nuclear localization of endogenous HARS in HUVECs. Scale bars, 50 μm.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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