FIGURE

Fig. 2

ID

ZDB-FIG-180706-41

Publication

Liu et al., 2018 - CRISPR/Cas9-induced shank3b mutant zebrafish display autism-like behaviors.

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Fig. 2

Morphological characteristics of shank3b^−/− larvae and adult zebrafish. a–b Abnormal morphological changes in shank3b^−/− and shank3b^+/− larvae at ~ 1 dpf, including severe developmental delay, eye melanin reduction (blue arrow), and tail bending (red arrow) (+/+, N = 60; +/−, N = 50; −/−, N = 50). c–d Normal morphology and body length of shank3b^+/+, shank3b^+/−, and shank3b^−/− larvae at 3 dpf (c) and adults (6 mpf, male) (d) (N = 20 for each genotype). e–f Significantly enlarged brain size (e) but normal brain weight (f) in adult male shank3b^−/− (6 mpf) compared to WT zebrafish (N = 30 for each genotype). *p < 0.05

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	shank3b^{fdu201/fdu201} (TU)
Observed In:	brain embryo development eye Melanin post-vent region whole organism
Stage Range:	Prim-5 to Adult

Phenotype Detail

Acknowledgments

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