FIGURE

Fig. 3

ID

ZDB-FIG-180626-7

Publication

Kellaris et al., 2018 - A hypomorphic inherited pathogenic variant in DDX3X causes male intellectual disability with additional neurodevelopmental and neurodegenerative features

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Fig. 3

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Fig. 3

Functional testing of DDX3X variants. a–c Representative lateral images of zebrafish embryos at 2 dpf that are either uninjected (a) or injected with human WNT3A without (b) or with (c) human DDX3X show a range of ventralized phenotypes. These were scored according to established criteria as normal, class I, or class II ventralization. No injection condition resulted in severe ventralization (class III or IV) [3]. d DDX3X variants were tested for their effect on increasing WNT3A-mediated ventralization using 550 fg of WNT3A mRNA and 30 pg of DDX3X mRNA per embryo. P values: < 0.0001 (four asterisks); 0.0001 to 0.001 (three asterisks); 0.001 to 0.01 (two asterisks); 0.01 to 0.05 (one asterisk); ≥ 0.05 not significant (ns)

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Genomics