FIGURE

Fig. 1

ID

ZDB-FIG-180522-36

Publication

Fadeev et al., 2018 - ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells

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Fig. 1

Ectopic expression of ALKALs and overactivation of DrLtk leads to supernumerary iridophores in D. rerio. (A) Domain structure of the human and zebrafish ALK/LTK RTK family. GR, glycine rich; L, LDLa; M, MAM; PTK, kinase domain; TM, transmembrane domain. The activating F993I (DrLtk) and F1174L (HsALK) mutations within the kinase domain are indicated. (B) ltk loss-of-function shady mutants (ltk^j9s1) lack iridophores, while gain-of-function moonstone (ltk^mne) exhibit increased numbers of iridophores. (C) Alignment of ALKAL proteins from different species. Underlined, the FAM150 domain; red asterisks, conserved Cys. Note high conservation of the C-terminal half of the FAM150 domain.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ltk^dtwc3/dtwc3 ltk^j9s1/j9s1
Observed In:	iridophore whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA