FIGURE

Fig. 3

ID

ZDB-FIG-180315-22

Publication

Cosacak et al., 2017 - Human TAU^P301L overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain.

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Fig. 3

Immunohistochemistry for PCNA (green), S100β (red), and TAU^P301L (white) on coronal sections of telencephalon of a 6 month-old sTg animal injected with PBS (a), sTg animal injected with Aβ42 (b), dTg animal injected with PBS (c), and dTg animal injected with Aβ42 (d). (e) Quantification of the total number of proliferating radial glial cells in the telencephalon of sTg and dTg animals injected with PBS or Aβ42. Values represent mean ± s.e.m. *p < 0.05, **p < 0.01, ***p < 0.005. Scale bars equal 100 μm. n = 5 fish and > 20 histological sections for every staining. All animals are 6 months old.

Expression Data

Antibodies:	Ab1-s100 Ab2-pcna Ab8-tau
Fish:	ced1Tg ced1Tg; ced2Tg
Conditions:	chemical treatment by environment: tamoxifen, chemical treatment by injection: amyloid-beta polypeptide 42 chemical treatment by environment: tamoxifen
Anatomical Terms:	telencephalon telencephalon radial glial cell
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ced1Tg ced1Tg; ced2Tg
Conditions:	chemical treatment by environment: tamoxifen, chemical treatment by injection: amyloid-beta polypeptide 42 chemical treatment by environment: tamoxifen
Observed In:	radial glial cell cell population proliferation
Stage:	Adult

Phenotype Detail

Acknowledgments

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