FIGURE

Fig. 7

ID

ZDB-FIG-180202-23

Publication

Sagar et al., 2017 - Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function

Other Figures

Fig. 7

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Fig. 7

ISD attenuates Adriamycin induced death and glomerular phenotype in zebrafish: (A) Adriamycin (30.3 mg/liter) was added to zebrafish embryos (8hpf) to induce mortality and glomerular phenotype. The Kaplan-Meier survival curve shows a significant reduction in Adriamycin induced mortality in ISD treated fish (p < 0.05). (B) Adriamycin induced phenotype is categorized into normal, moderate and severe pericardial edema. Quantitative analysis suggests that ISD reduced moderate and severe phenotypes by more than 50%. (C) Histological analysis further revealed a significant reduction in the Adriamycin induced pronephric tubular dilation (a hallmark of renal injury, shown by arrow) and glomerular architecture damage (marked as G).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment by environment: doxorubicin chemical treatment by environment: isodesmosine
Observed In:	pericardium pronephric tubule whole organism
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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