FIGURE

Fig. 2

ID

ZDB-FIG-170829-11

Publication

Yu et al., 2017 - Wolf-Hirschhorn Syndrome Candidate 1 (whsc1) Functions as a Tumor Suppressor by Governing Cell Differentiation

Other Figures

(all 8)

All Figure Page

Back to All Figure Page

Fig. 2

WHS related phenotypes in whsc1^−/− zebrafish. (A) Brain morphology in whsc1^−/− and wild-type embryos. Arrow heads point to the diencephalic ventricle (homologue of mammalian third ventricle). (B) Motor neuron development in whsc1^−/− and wild-type embryos. Note that the number of motor neurons in whsc1^−/− mutant larva was significantly less than that in wild-type ones. (C) whsc1^−/− adult zebrafish showed heart enlargement. (D) Tissue section analysis of the heart of wild-type or mutant adult fishes. Arrows point to the hearts. (E) Statistics of heart enlargement in these two mutation lines.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nsd2^{zf2077/zf2077} nsd2^{zf2078/zf2078} nsd2^{zf2077/zf2077}; zf2076Tg nsd2^{zf2078/zf2078}; zf2076Tg
Observed In:	cardiac muscle cardiac ventricle heart motor neuron pericardium third ventricle (all 6)
Stage Range:	20-25 somites to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Neoplasia