FIGURE

Fig. S14

ID

ZDB-FIG-170519-2

Publication

Vazão et al., 2017 - High-throughput identification of small molecules that affect human embryonic vascular development

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Fig. S14

Effect of 7-Cyclo in the vasculature of adult zebrafish. Tg(fli1a:EGFP) Danio rerio caudal fins were resected (dotted line) and analysed 5 days after amputation, in the presence of 0.1 μM 7-Cyclo inhibitor (a.1 and a.4) and in DMSO (a.2 and a.3). The effect of 7- Cyclo is considerably stronger in regenerating vasculature when compared with its effect on preformed vasculature. (b) Fluorescence images were quantified using IMARIS software, surface masks and visual correction to determine vascular area. Results are mean ± SEM (n=6 animals per experimental group). Statistical analyses were performed by one-way ANOVA test followed by a Bonferroni multiple comparisons test. * P <0.01, *** P <0.001. The difference of the differences in "forming vasculature" group or "pre-formed vasculature" are statistical significant (P<0.024), thus, the difference between DMSO and 7-Cyclo for "pre-formed vasculature" group is lower than the difference between DMSO and 7-Cyclo for "forming vasculature" group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA