FIGURE

Fig. 5

ID

ZDB-FIG-170209-18

Publication

Sotolongo-Lopez et al., 2016 - Genetic Dissection of Dual Roles for the Transcription Factor six7 in Photoreceptor Development and Patterning in Zebrafish

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Fig. 5

six7 acts cell autonomously.

(A) six7^fl4-donor cells or (B) WT-donor cells were labeled by the tracer rhodamine-dextran, transplanted into WT genetic background and allowed to develop until 4 dpf. Expression of rods (4C12, green) and green-sensitive opsin (pink) were detected by whole mount immunolabeling. Note that six7^fl4-transplanted cells frequently differentiate as rod photoreceptors (orange, arrows) and rarely immunolabeled for green-sensitive opsins while neighboring WT cells differentiate as green-sensitive cones. Significant difference was observed in the percent of six7^fl4-donor cells that differentiate into rods or cones compared to WT donor cells (χ², p<0.0001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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