FIGURE

Fig. 3

ID

ZDB-FIG-160204-1

Publication

Boyd et al., 2015 - Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness

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Fig. 3

Reverse-transcription quantitative PCR (RT-qPCR) analysis demonstrates that disc1 expression is altered in sonic hedgehog pathway mutants. (A) Graphical representation demonstrating that expression of disc1 was below the threshold for detection in smo^b641 mutant embryos at 50hpf. (B) Expression of disc1 was 0.65-fold lower in ptch1;ptch2 double mutants than siblings (P=0.0027). Both ptch1;ptch2 mutant (C; 1.8-fold, P=0.035) and sibling (D; 2.4-fold, P<0.0001) pools show increased disc1 expression relative to smo^b641 sibling embryos at 50hpf. (n=4; *P<0.05, **P<0.005, ****P<0.0001; error bars show s.e.m.).

Expression Data

Gene:	disc1
Fish:	WT smo^b641/b641 ptch1^tj222/+; ptch2^{hu1602/hu1602}
Anatomical Term:	whole organism
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	smo^b641/b641 ptch1^tj222/+; ptch2^{hu1602/hu1602}
Observed In:	whole organism
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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