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Fig. 1

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ZDB-FIG-151106-2

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Boije et al., 2015 - The Independent Probabilistic Firing of Transcription Factors: A Paradigm for Clonal Variability in the Zebrafish Retina

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Fig. 1

Blastomere Transplantation Allows Clonal Analysis of RPCs

(A) A core network of four key TFs can explain much of the cellular diversity in the retina.

(B) Cells from H2B-GFP, Ptf1a-dsRed double transgenic embryos were transplanted into WT embryos at 3.5 hpf.

(D) At 72 hpf differentiation is completed with radial clones generated by transplanted cells. The asterisk marks a dAC.

(E) Quantification of cell fate distribution in clones generated by WT RPCs into WT hosts. Cell numbers and SDs are indicated as are the percentages of an average clone. Un, unknown. Scale bars represent 20 µm in (C) and 5 µm in (D).

See also Tables S1 and S2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 34(5), Boije, H., Rulands, S., Dudczig, S., Simons, B.D., Harris, W.A., The Independent Probabilistic Firing of Transcription Factors: A Paradigm for Clonal Variability in the Zebrafish Retina, 532-43, Copyright (2015) with permission from Elsevier. Full text @ Dev. Cell