FIGURE

Fig. 9

ID

ZDB-FIG-150413-48

Publication

Jackson et al., 2015 - The role of Sox6 in zebrafish muscle fiber type specification

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Fig. 9

Disruption of fiber type identity in adultsox6mutant fish. (A,B) at 3 months, expression of the tnnc1b:eGFP reporter is restricted to the medio-lateral wedge of slow-twitch fibers in wild-type fish. (C,D) In sox6 mutants, the reporter gene is also expressed at lower levels in fast-twitch fibers while the slow-twitch fibers extend closer to the midline. The diameter of the slow-twitch fibers is significantly reduced compared to wild-type (cf. B and D). (E) The smyhc1:GFP reporter is expressed at high levels in the slow-twitch fiber of 2-month-old fish. (F) the reporter shows a similar pattern of expression in sox6 mutants at the same stage, with lower level expression extending more medially than in wild type.

Expression Data

Gene:	EGFP
Fish:	i104Tg i293Tg sox6^i291/i291; i104Tg sox6^i291/i291; i293Tg
Anatomical Terms:	fast muscle cell slow muscle cell
Stage Range:	Days 45-89 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sox6^i291/i291; i104Tg sox6^i291/i291; i293Tg
Observed In:	fast muscle cell slow muscle cell
Stage Range:	Days 45-89 to Adult

Phenotype Detail

Acknowledgments

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