FIGURE

Fig. 2

ID

ZDB-FIG-140211-7

Publication

Breau et al., 2013 - A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling

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Fig. 2

Overexpression of Hoxb8a leads to down-regulation of cxcr7b. (A) Fluorescent images of cldnb:lyngfp in cldnb4.2:gal4 x UAS:Hoxb8aMT embryos and control siblings at 45 hpf. The blue arrowhead shows the yolk defect seen in all cldnb4.2:gal4 x UAS:Hoxb8aMT embryos. Red arrowheads indicate the position of the primordium. (B) Quantification of the migration at 45 hpf (control, n = 20; cldnb4.2:gal4 x UAS:Hoxb8aMT, n = 26). Expression of (C) cxcr4b, (D) cxcr7b, and (E) lef1 in cldnb4.2:gal4 x UAS:Hoxb8aMT and control siblings at 28 hpf. ISH was followed by Myc immunostaining (brown). (Scale bar: 25 µm.)

Expression Data

Genes:	ackr3b cxcr4b EGFP lef1
Antibody:	Ab1-myc
Fish:	zf106Tg zf106Tg + MO2-hoxb8a nim11Tg; nim12Tg; zf106Tg
Knockdown Reagent:	MO2-hoxb8a
Anatomical Terms:	posterior lateral line primordium posterior lateral line primordium posterior-most region
Stage Range:	Prim-5 to High-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nim11Tg; nim12Tg; zf106Tg
Observed In:	posterior lateral line neuromast primordium migration
Stage:	High-pec

Phenotype Detail

Acknowledgments

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