Fig. 7

Evidence that Fibronectin does not directly regulate cardiomyocyte proliferation during regeneration. (A and B) Assessment of Mef2⁺PCNA⁺ cells (arrows) in hsp70:fn^I1–9 (A) and clutchmate (B) 7 dpa ventricles. Insets, enlarged view of the rectangle. Brackets indicate injury site. (C) Quantification of cardiomyocyte proliferation in hsp70:fn^I1–9 and clutchmate 7 dpa ventricles. For each group, 6 zebrafish were assessed. Student′s t-test, p=0.23. Mean±s.e.m. (D and E) Assessment of Mef2⁺PCNA⁺ cells (arrows) in wild-type (D) and homozygous fn1 mutant (E) 7 dpa ventricles. Brackets indicate injury site. (F) Quantification of cardiomyocyte proliferation in wild-type and homozygous fn1 mutant 7 dpa ventricles. For each group, 3–4 zebrafish were assessed. Student′s t-test, p=0.99. Mean±s.e.m. Scale bars: 50 μm.