FIGURE

Fig. 2

ID

ZDB-FIG-131108-30

Publication

Anchelin et al., 2013 - Premature aging in telomerase-deficient zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Premature aging signals in tert mutant zebrafish. (A) Kaplan-Meier representation of the survival of three genetic backgrounds. Post-hatching time is shown in weeks. A dashed line indicates 50% survival. The Log Rank test was used for statistical analysis. (B) Representative image of a tert^+/+ and a tert^-/- zebrafish at 11 months old. (C) Liver sections stained with H&E showed cytoplasmic vacuolization of hepatocytes (3) and were PAS-positive (6, white asterisks). H&E-stained eye sections revealed a decreased thickness of both retinal pigmented epithelium (rpe) and the photoreceptor layer (prl), which had a disorganized appearance (9, white arrowheads). Representative images are from at least three fish per genotype.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tert^{hu3430/hu3430}
Observed In:	determination of adult lifespan hepatocyte retina retinal photoreceptor layer retinal pigmented epithelium spinal cord whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.