FIGURE

Fig. 3

ID

ZDB-FIG-120315-47

Publication

Simmons et al., 2012 - Mutation of pescadillo Disrupts Oligodendrocyte Formation in Zebrafish

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Fig. 3

Loss of pes function reduces oligodendrocyte gene expression.

Transverse sections through spinal cords of 4 dpf wild-type (A–C) and pes^{vu166 -/-} (D–F) larvae processed for in situ RNA hybridization. Arrowheads indicate oligodendrocytes. Reaction products are greatly reduced in mutant relative to wild type. (G) Average number of labeled cells in the dorsal and ventral spinal cord. Ten sections from ten larvae of each genotype were counted. Asterisk (*) indicates pj0.05 by Student′s T-test. (H) Relative expression levels of the CNS myelin genes mpz and 36k measured by quantitative PCR.

Expression Data

Genes:	cldnk dhrs12la mbpa mpz plp1a
Fish:	AB pes^vu166/vu166 (AB)
Anatomical Terms:	central nervous system myelin sheath oligodendrocyte
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pes^vu166/vu166 (AB)
Observed In:	central nervous system oligodendrocyte oligodendrocyte myelin sheath oligodendrocyte differentiation
Stage:	Day 4

Phenotype Detail

Acknowledgments

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