FIGURE

Fig. 6

ID
ZDB-FIG-120216-59
Publication
Langenbacher et al., 2012 - Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis
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Fig. 6

Atp1a1 expression by the YSL is regulated by mxtx1. (A–D) Microtome sections of atp1a1 expression in 95% epiboly (A,B) and 19S stage (C,D) wild type and mxtx1MOYSL embryos. Nuclei are labeled red by neutral red staining. Expression of atp1a1 (purple staining, arrowheads) is present in the YSL of wild type embryos at 95% epiboly (A) and the 19S stage (C). The expression of atp1a1 in the YSL is strongly reduced in mxtx1MOYSL embryos at the same stages (B,D). (G) Summary of Atp1a1 function. Atp1a1 expression in the YSL is regulated by mxtx1, and is required for the deposition of Fn/ECM around the developing heart. This ECM deposition is critical for normal heart tube elongation. Atp1a1 also has a cell autonomous role within cardiomyocytes to regulate the contractility of the heart.

Expression Data
Gene:
Fish:
Knockdown Reagent:
Anatomical Term:
Stage Range: 90%-epiboly to 14-19 somites

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 362(2), Langenbacher, A.D., Huang, J., Chen, Y., and Chen, J.N., Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis, 263-270, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.