FIGURE

Fig. 6

ID

ZDB-FIG-120131-15

Publication

Pan et al., 2012 - Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons

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Fig. 6

Robo2 regulates subtype-specific projection patterns. (A-B′) Trigeminal axonal morphology in wild-type and robo2^-/- zebrafish. Red arrowheads point to branches. Trpa1b axonal morphology in robo2^-/- is indistinguishable from that of wild type (A,A′). By contrast, there is a noticeable increase in branch length and varicosity number in the Isl1SS subtype in robo2^-/- (B,B′). (C-E) Comparison of Trpa1b morphology in wild type (green) versus robo2^-/- (black). No differences were seen in varicosity number (C), branch number (D) or branch length (E). (F-H) Comparison of Isl1SS morphology in wild type (magenta) versus robo2^-/- (black). Significant differences were seen in varicosity number (F) and branch length (H), but not branch number (G). Error bars indicate s.e.m. ^*, P<0.05; ^***, P<0.001. Scale bars: 100 μm.

Expression Data

Genes:	EGFP Kaede
Fish:	a128Tg a129Tg robo2^{ti272z/ti272z}; a128Tg robo2^{ti272z/ti272z}; a129Tg
Anatomical Term:	trigeminal ganglion axon
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	robo2^{ti272z/ti272z}; a128Tg robo2^{ti272z/ti272z}; a129Tg
Observed In:	collateral sprouting in absence of injury sensory neuron presynaptic active zone synapse assembly trigeminal ganglion axon trigeminal ganglion axon collateral trigeminal ganglion sensory neuron (all 6)
Stage:	Day 5

Phenotype Detail

Acknowledgments

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