FIGURE

Fig. 2

ID

ZDB-FIG-111115-9

Publication

Gutierrez et al., 2011 - Aberrant AKT activation drives well-differentiated liposarcoma

Other Figures

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Fig. 2

Osteosarcoma development in a rag2:myr-mAkt2-injected, p53-homozygous mutant zebrafish. (A and B) A p53-homozygous mutant zebrafish injected with the rag2:myr-mAkt2 expression construct developed a solid lobulated mass at the base of the dorsal fin. Note that the image shown in A consists of merged adjacent photomicrographs. (Scale bars, 1 mm.) (C and D) H&E-stained sections at low and high magnification, respectively, demonstrate a mass consisting predominantly of osteoid matrix interspersed with large malignant cells with pleomorphic nuclei, features that in humans are diagnostic of osteoblastic osteosarcoma. (Scale bars, 100 μm.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA