FIGURE

Fig. 7

ID

ZDB-FIG-111014-7

Publication

Valdivia et al., 2011 - Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development

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Fig. 7

Lef1 is epistatic to APC in controlling leading zone cell behaviour. (A,B) Histogram depicting the number/position of neuromasts in apc^CA50a (A) and apc^CA50a mutant/lef1-morphant (B) embryos. Arrows indicate the average position and colours denote the different populations of sequentially deposited neuromasts. (C,D) apc^CA50a (C) and apc^CA50a mutant/lef1-morphant (D) Tg(-8.0cldnb:lynEGFP)^zf106 embryos showing groups of cells migrating caudally after the primordium has stalled (arrowheads). Arrow in D indicates the extended trail of cells in morphants.

Expression Data

Gene:	EGFP
Fish:	apc^zf134/zf134; zf106Tg apc^zf134/zf134; zf106Tg + MO3-lef1
Knockdown Reagent:	MO3-lef1
Anatomical Term:	posterior lateral line primordium
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	apc^zf134/zf134; zf106Tg apc^zf134/zf134; zf106Tg + MO3-lef1
Knockdown Reagent:	MO3-lef1
Observed In:	posterior lateral line development posterior lateral line neuromast primordium migration
Stage:	Prim-25

Phenotype Detail

Acknowledgments

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