FIGURE

Fig. 8

ID
ZDB-FIG-110920-34
Publication
McGraw et al., 2011 - Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium
Other Figures
All Figure Page
Back to All Figure Page
Fig. 8

Lef1 is required to maintain progenitor cell identity. (A-D) Confocal projections of Tg(–8.0cldnb:lynGFP)-positive, mosaic embryos containing either wild-type or lef1nl2 donor cells (red) at 24 and 48 hpf. (A) Wild-type host primordium at 24 hpf with wild-type donor cells in the leading region (yellow bracket). (B) Chimeric primordium containing lef1nl2 mutant cells in the leading region at 24 hpf (yellow bracket). At 48 hpf, wild-type donor cells remain in the leading region (C; yellow bracket), whereas lef1nl2 cells have moved out of the leading region (D; yellow bracket). (E-F′) Confocal projections of chimeric primordia containing wild type Tg(hsp70l:dkk1-GFP) donor cells. Embryos were heat-shocked at 28 hpf. (E) Primordium containing wild-type cells and a characteristic rounded morphology. (F) Wild-type primordium containing Tg(hsp70l:dkk1-GFP) donor cells shows loss of primordium organization. (F′) Contralateral side of the chimera shown in F is normal. Scale bars: 20 μm.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development