FIGURE

Fig. 2

ID

ZDB-FIG-110804-34

Publication

Garkavtsev et al., 2011 - Dehydro-α-lapachone, a plant product with antivascular activity

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Fig. 2

DAL impairs vessel development and regeneration in zebrafish. (A) Macroscopic view of 48 h after fertilization Tg(fli1:EGFP)^y1 zebrafish embryos, comparing control embryos and embryos treated with DAL (5 μM). Treated embryos failed to form vessel branches. (B and C) Regeneration experiments with zebrafish, depicting the vasculature of the caudal fin on 2 and 9 d after amputation in control and treated zebrafish. White lines indicate the amputation plane. (B) Vascular plexus formation, plexus remodeling, and late regenerative angiogenesis. (C) A higher magnification of the reconnected vessels. Nine days after amputation, the regenerating vasculature of each fin ray (three fin rays are shown) consists of a plexus with dense unstructured vessels extending distally from the amputation plane (white arrowheads). Regenerating blood vessels in the wild-type control (fli1:EGFP) form plexuses. Fish treated with DAL have defects in anastomosis and plexus formation. (Scale bars: 200 μm.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA