ZFIN Figure: Takeuchi et al., 2011, Fig. 2

ZFIN ID: ZDB-FIG-110316-4

ZFIN ID: ZDB-FIG-110316-4

Takeuchi et al., 2011 - Chromatin remodelling complex dosage modulates transcription factor function in heart development. Nature communications 2:187 Full text @ Nat. Commun.

ADDITIONAL FIGURES

EXPRESSION / LABELING:

Genes:	bmp4 EGFP myh6 myl7 notch1b nppa slc8a1a tbx2b
Fish:	twu34Tg/+ WT smarca4a^s481/s481 s843Tg smarca4a^s481/s481; s843Tg smarca4a^s481/s481; twu34Tg
Anatomical Terms:	atrioventricular canal atrium cardiac conduction system electrically active cell cardiac ventricle endocardium heart myocardium
Stage Range:	Long-pec to Protruding-mouth

PHENOTYPE:

Fish:	smarca4a^s481/s481 smarca4a^s481/s481; s843Tg
Observed In:	atrioventricular canal heart heart looping pericardium
Stage Range:	Long-pec to Day 5

Fig. 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details

Gene	Fish	Conditions	Stage	Qualifier	Anatomy	Assay
bmp4	WT	standard conditions	Long-pec		atrioventricular canal	ISH
			Long-pec		cardiac conduction system electrically active cell	ISH
	smarca4a^s481/s481	standard conditions	Long-pec		cardiac conduction system electrically active cell	ISH
			Long-pec		cardiac ventricle	ISH
EGFP	s843Tg	standard conditions	Long-pec		endocardium	IFL
	smarca4a^s481/s481; s843Tg	standard conditions	Long-pec		endocardium	IFL
	smarca4a^s481/s481; twu34Tg	standard conditions	Long-pec		myocardium	IFL
	twu34Tg/+	standard conditions	Long-pec		myocardium	IFL
myh6	WT	standard conditions	Long-pec		atrium	ISH
	smarca4a^s481/s481	standard conditions	Long-pec		atrium	ISH
myl7	WT	standard conditions	Long-pec		cardiac ventricle	ISH
	smarca4a^s481/s481	standard conditions	Long-pec		cardiac ventricle	ISH
notch1b	WT	standard conditions	Protruding-mouth		atrioventricular canal	ISH
	smarca4a^s481/s481	standard conditions	Protruding-mouth	Not Detected	atrioventricular canal	ISH
nppa	WT	standard conditions	Long-pec	Not Detected	atrioventricular canal	ISH
			Long-pec		atrium	ISH
			Long-pec		cardiac ventricle	ISH
			Long-pec		myocardium	ISH
	smarca4a^s481/s481	standard conditions	Long-pec		atrioventricular canal	ISH
			Long-pec		atrium	ISH
			Long-pec		cardiac ventricle	ISH
			Long-pec		myocardium	ISH
slc8a1a	WT	standard conditions	Protruding-mouth		heart	ISH
	smarca4a^s481/s481	standard conditions	Protruding-mouth		heart	ISH
tbx2b	WT	standard conditions	Long-pec		atrioventricular canal	ISH
	smarca4a^s481/s481	standard conditions	Long-pec		atrioventricular canal	ISH

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
smarca4a^s481/s481	standard conditions	Long-pec	atrioventricular canal increased length, abnormal
		Long-pec	heart looping disrupted, abnormal
		Long-pec	heart morphology, abnormal
		Protruding-mouth	atrioventricular canal increased length, abnormal
		Protruding-mouth	heart looping disrupted, abnormal
		Protruding-mouth	heart morphology, abnormal
		Day 5	pericardium edematous, abnormal
smarca4a^s481/s481; s843Tg	standard conditions	Long-pec	heart constricted, abnormal
		Long-pec	heart morphology, abnormal

Full text @ Nat. Commun.