FIGURE

Fig. S5

ID

ZDB-FIG-110128-15

Publication

Haud et al., 2011 - rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA

Other Figures

All Figure Page

Back to All Figure Page

Fig. S5

Comparable MR presentations of RNase T2-deficient human and zebrafish. (A) Axial T₂-weighted cerebral MR image of a patient with RNASET2-deficient cystic leukoencephalopathy. The image indicates multifocal white matter abnormalities adjacent to the ventricles (black arrows) and in deep white matter (white arrows). (Scale bar: 1 cm). (B) T₂ relaxation time measurement of the brain of a mutant zebrafish containing nullizygous mutation in rnaset2 gene. Sagittal MR image of the brain of an adult AO127 mutant zebrafish indicate the presence of lesions adjacent to the ventricles (white arrows) and were of similar intensity as that of CSF present in ventricles. (Boxed area, enlarged at right.) Areas were selected for T₂ relaxation time measurements within healthy brain region (1, 2), in ventricles (4), and in lesion outside (3) or adjacent to ventricle (5). The lesions adjacent to ventricles have similar T₂ relaxation time as that of ventricles, suggesting that these lesions may be filled with solution similar to CSF.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rnaset2^umc4/umc4
Observed In:	amyloid precursor protein metabolic process
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA