FIGURE

Fig. 5

ID

ZDB-FIG-101007-7

Publication

Ramesh et al., 2010 - A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

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Fig. 5

Motor neuron loss was observed in G93R os10 spinal cord at the disease end-stage. (A) ChAT immunohistochemistry of anterior spinal cord sections from adult G93R os10 fish and nTg siblings demonstrates reduced numbers of positively labeled motor neurons (denoted by arrows) in end-stage fish compared with controls. (B) ChAT-positive motoneurons (≥10 μm diameter) from anterior spinal cord sections (20 μm thickness) of adult end-stage fish were blinded to genotype and counted (*P<0.0001, n=40 sections per fish, three fish per genotype). Data are mean ± s.e.m. Bar, 200 μm.

Expression Data

Gene:	chata
Antibody:	Ab1-chat
Fish:	WT os10Tg
Anatomical Term:	spinal cord motor neuron
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	os10Tg
Observed In:	spinal cord motor neuron
Stage:	Adult

Phenotype Detail

Acknowledgments

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