Mutations affecting chondrogenesis. (A) Mutants are shorter and have reduced jaw structures. Wild-type (bottom) and mutant mr hyde205 larva (top) at day 5 of development. The mutant is shorter and has a reduced jaw. Wild-type embryos have an inflated swim bladder. (C) Dorsal view of wild-type day-5 larva. (D) Dorsal view of a day-5 mr hyde205 larva. Notice the rostral position of the eyes and the smaller and bent pectoral fins. (B,E-Q). Ventral views of Alcian blue stained larvae at day 5 of development. (B) Wild-type larva. (E-M) Mutant larvae defective in cartilage formation. Skeletal elements appear smaller and are weakly stained. (E) bulldog494, the ceratobranchials are present but smaller; (F) mr hydem205; (G) roundm713; (H) crusherm299; (I) jekyllm151; (J) zhivagom315; (K) stumpfm365; (L) strangelovem617 and (M) feelgoodm662. N-Q depict mutant larvae that display stunted growth of skeletal elements. (N) apparatchikm364; (O) rieuxm526 (notice the thicker and shorter ceratohyal) and (P) kimblem533. (Q) In postdocm485 the pharyngeal skeleton is reduced and the ceratohyal is bent ventrally. The pectoral fin is reduced. wt, wild-type; ch, ceratohyal; cb, ceratobranchials; mk, Meckel’s cartilage; pec fin; pectoral fin and qu, quadrate. Scale bars, 100 μm.