ZFIN ID: ZDB-FIG-090320-72
Jing et al., 2009 - Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor. Neuron   61(5):721-733 Full text @ Neuron
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Anatomical Terms:
Stage: 14-19 somites
PHENOTYPE:
Fish:
Observed In:
Stage: 14-19 somites

Fig. 2 unplugged Restricts Navigating Growth Cones to a Central Muscle Zone

(A–D) Still images from time-lapse movies showing the initial migration of single CaP axons (A and B) or CaP/VaP pair axons (C and D) from the spinal cord into the myotome. Arrows point to the single wild-type CaP growth cone (A) and to the tightly fasciculated wild-type CaP/VaP growth cones (C). In contrast, unplugged CaP neurons form extensive filopodia and even multiple growth cones (arrowheads) that occupy a broader area (brackets, [B]). Similary, mutant CaP/VaP growth cones appear defasciculated and occupy a broader area compared to wild-type. Asterisks indicate interneurons also labeled by the Tg(Hb9:GFP) transgene.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GFP ml2Tg standard conditions 14-19 somites CaP motoneuron axon IFL
14-19 somites CaP motoneuron growth cone IFL
14-19 somites CaP motoneuron neuronal cell body IFL
musktbr307/tbr307; ml2Tg standard conditions 14-19 somites CaP motoneuron axon IFL
14-19 somites CaP motoneuron growth cone IFL
14-19 somites CaP motoneuron neuronal cell body IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
musktbr307/tbr307; ml2Tg standard conditions 14-19 somites CaP motoneuron growth cone malformed, abnormal
14-19 somites motor neuron axon guidance process quality, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Neuron