FIGURE
Fig. 8
- ID
- ZDB-FIG-080702-32
- Publication
- Lee et al., 2008 - Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye
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Fig. 8
atp6v0b morpholinos do not phenocopy blowout. (A) The atp6v0b predicted genomic organization. atp6v0b MO targets the exon1/intron1 splice junction and leads to the inclusion of a 705 bp intron1 and the introduction of a premature stop codon. (B) RT-PCR validation of splice blocking efficacy of the atp6v0b MO. (C) Control injected and (D) atp6v0b morphant (13 ng) at 5 dpf. Morphants display oculocutaneous albinism and retinal degeneration but show no signs of colobomas even at the highest doses of MO injection. |
Expression Data
| Gene: | |
|---|---|
| Fish: | |
| Knockdown Reagent: | |
| Anatomical Term: | |
| Stage Range: | Prim-5 to Long-pec |
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
|---|---|
| Knockdown Reagent: | |
| Observed In: | |
| Stage: | Day 5 |
Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 319(1), Lee, J., Willer, J.R., Willer, G.B., Smith, K., Gregg, R.G., and Gross, J.M., Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye, 10-22, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.