FIGURE

Fig. 7

ID
ZDB-FIG-080701-28
Publication
McFarland et al., 2008 - Hh and Wnt signaling regulate formation of olig2(+) neurons in the zebrafish cerebellum
Other Figures
All Figure Page
Back to All Figure Page
Fig. 7

Inhibition of Hh signaling causes expansion of the wnt1 expression domain. All embryos shown are 48 hpf. Black arrows in whole mount views depict the morphological line of the midbrain adjoining the midbrain–hindbrain boundary. Lateral whole mount (A), dorsal whole mount (B), transverse section (C) and sagittal section (D) showing wnt1 expression in control embryos. The black arrows mark the base of the 3rd ventricle, with which the ventral extent of wnt1 expression coincides in the midbrain–hindbrain region. (E–H) Similar views of wnt1 expression in embryos treated with CA beginning at 6 hpf. wnt1 expression in the midbrain–hindbrain region is expanded both ventrally and posteriorly. (I, J) Expression of wnt1 in embryos that overexpressed Dkk1 at 30 hpf was similar to controls. (K, L) wnt1 expression was expanded in embryos treated with CA at 6 hpf and heat shocked to induce Dkk1 expression at 30 hpf. Scale bars represent 20 μm in all panels.

Expression Data
Gene:
Fish:
Conditions:
Anatomical Term:
Stage: Long-pec

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Conditions:
Observed In:
Stage: Long-pec

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 318(1), McFarland, K.A., Topczewska, J.M., Weidinger, G., Dorsky, R.I., and Appel, B., Hh and Wnt signaling regulate formation of olig2(+) neurons in the zebrafish cerebellum, 162-171, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.