FIGURE

Fig. 1

ID

ZDB-FIG-080514-24

Publication

Rawls et al., 2001 - How the zebrafish gets its stripes

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Fig. 1

Zebrafish mutants affect distinct classes of adult stripe melanocytes. Adult wild-type zebrafish (WT) have melanocyte stripes in the body, and in the caudal and anal fins. Adult homozygous mitf^w2 (nacre) mutants [mitf (nacre)] lack all neural crest-derived melanocytes. Several zebrafish mutants develop around half the normal complement of adult body stripe melanocytes, lacking either early stripe melanocytes (ESMs) or late stripe melanocytes (LSMs). Homozygous fms^j4e1 (panther) mutants [fms (panther)] and ednrb1^b140 (rose) mutants [ednrb1 (rose)] lack LSMs, while kit^b5 (sparse) mutants lack ESMs and dorsal scale-associated melanocytes [kit (sparse)]. Adults homozygous for both kit^b5 and ednrb1^b140 lack all body stripe melanocytes (kit;ednrb1), demonstrating that the melanocyte classes absent in each of the respective single mutants are genetically distinct. Note that the kit;ednrb1 double mutants retain melanocyte stripes in the caudal and anal fins, revealing a third class of adult melanocytes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 240(2), Rawls, J.F., Mellgren, E.M., and Johnson, S.L., How the zebrafish gets its stripes, 301-314, Copyright (2001) with permission from Elsevier. Full text @ Dev. Biol.