FIGURE

Fig. 7

ID

ZDB-FIG-080505-52

Publication

Hawkins et al., 2008 - The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish

Other Figures

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Fig. 7

Inhibition of the FGF pathway by SU5402 does not show any similarities to U0126-treated embryos. A-C: Expression of the Fgf-pathway target gene sef is downregulated in SU5402 (C) but not in U0126-treated (B) embryos. D-I: Expression of the notochordal marker genes col2a1 (D-F) and shh (G-I) also show different defects in SU5402 and U0126-treated embryos. J-M: Expression of lox1 (J, K) and lox5b (L-M) is not decreased normally by U0126-treatment. N, O: copa mRNA persists and is not downregulated by U0126-treatment.

Expression Data

Genes:	col2a1a copa il17rd loxl1 loxl5b shha (all 6)
Fish:	WT
Conditions:	chemical treatment: SU5402 chemical treatment: (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile
Anatomical Terms:	floor plate hypochord notochord tail bud
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment: SU5402 chemical treatment: (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile
Observed In:	notochord
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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