FIGURE

Fig. 8

ID

ZDB-FIG-080107-12

Publication

Grandel et al., 2002 - Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud

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Fig. 8

In situ hybridisations at tail bud stage of (A,E,I) wild-type embryos and (B-D,F-H,J-L) embryos with compromised RA signalling. Dorsal views, anterior is to the top. Red lines refer to distances observed in wild-type embryos and are of the same length within each row of embryos. Homozygous nof, 5x10^–6 M BMS493-treated or morpholino-injected embryos downregulate hoxb1a (B-D) and hoxb1b (F-H) expression compared with wild-type siblings (A,E). (I-L) Length of the prospective hindbrain territory between pax2.1 and val domains is longer in homozygous nof, 5x10^–6 M BMS493-treated or morpholino-injected embryos (J-L) than in wild types (I) at the end of gastrulation.

Expression Data

Genes:	hoxb1a hoxb1b mafba otx2b pax2a
Fish:	WT aldh1a2^u11/u11 WT + MO1-aldh1a2
Knockdown Reagent:	MO1-aldh1a2
Anatomical Terms:	midbrain hindbrain boundary neural keel neural keel neuroectoderm presumptive rhombomere 5 presumptive rhombomere 6
Stage:	Bud

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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