FIGURE

Fig. 4

ID

ZDB-FIG-070914-51

Publication

Van Raay et al., 2007 - Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling

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Fig. 4

Nkds inhibit late canonical Wnt/β-catenin signaling. (A, B) Standard 1 to 2 cell overexpression of nkd1 or nkd2a RNA significantly expands gsc expression at 50% epiboly (B) compared with uninjected control siblings (A). (C) Injection of nkd1 MO, nkd2 MO and nkd1 or nkd2a RNA that is insensitive to the MOs results in an even larger expansion of gsc expression at 50%. (A–C) Dorsal view. This data is quantified in panel D. Error bars represent standard deviation (Students t-test, *, p < 0.05; ***, p < 0.0001).

Expression Data

Gene:	gsc
Fish:	AB AB + MO2-nkd1 + MO2-nkd2a AB + MO2-nkd1 + MO3-nkd2a
Knockdown Reagents:	MO2-nkd1 MO2-nkd2a MO3-nkd2a
Anatomical Term:	margin
Stage:	50%-epiboly

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 309(2), Van Raay, T.J., Coffey, R.J., and Solnica-Krezel, L., Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling, 151-168, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.