FIGURE

Fig. 3

ID

ZDB-FIG-051123-3

Publication

Norton et al., 2005 - HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development

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Fig. 3

fgf10/dae mutant embryos have reduced expression of AER markers. Lateral views of wild-type (B,E,G,K,I,M,O,S,Q,U,W) and mutant fins (C,F,H,L,J,N,P,T,R,V,X), with anterior towards left. At 28 hpf, expression of fgf24 and bmp2b appears indistinguishable in wild-type and fgf10/dae (A,D). Expression of sp8 is weakly reduced in dae (H) but sp9 (L), dlx2a (P) and wnt3l (T) expression is strongly reduced in mutants. By 38 hpf, expression of all ridge markers analysed is reduced in fgf10/dae (C,F,J,N,R,V,X) when compared with siblings (B,E,I,M,Q,U,W).

Expression Data

Genes:	bmp2b dlx2a fgf8a fgf24 sp8a sp9 wnt3a (all 7)
Fish:	WT fgf10a^tbvbo/tbvbo
Anatomical Terms:	pectoral fin pectoral fin bud
Stage Range:	Prim-5 to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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