CRISPR

CRISPR2-nr4a1

ID

ZDB-CRISPR-230106-1

Name

CRISPR2-nr4a1

Previous Names

None

Target

nr4a1 (1)

Sequence

5' - GAAGGAGTCCAGCTGCCCGG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
xmu201	nr4a1

Expression

Gene expression in Wild Types + CRISPR2-nr4a1

No data available

Phenotype

Phenotype resulting from CRISPR2-nr4a1

No data available

Phenotype of all Fish created by or utilizing CRISPR2-nr4a1

Phenotype	Fish	Conditions	Figures
whole organism gpib expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 5 from Xu et al., 2022
whole organism insb expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 6 from Xu et al., 2022
whole organism chia.4 expression increased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 5 from Xu et al., 2022
whole organism glucose increased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 5 from Xu et al., 2022
whole organism hmgcs1 expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 , Figure 4 , Figure 5 from Xu et al., 2022
whole organism chia.5 expression increased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 5 from Xu et al., 2022
whole organism leucine decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism lss expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 4 from Xu et al., 2022
whole organism lysine decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism alanine decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism ugt5a1 expression increased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 4 from Xu et al., 2022
whole organism ldha expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism aldoaa expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 5 from Xu et al., 2022
whole organism cyp51 expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 4 from Xu et al., 2022
whole organism proline decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism pygma expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 5 from Xu et al., 2022
whole organism tyrosine decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism cyp2p9 expression increased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 4 from Xu et al., 2022
whole organism phenylalanine decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism aox5 expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism methionine decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism cholesterol increased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 4 from Xu et al., 2022
whole organism triglyceride increased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 4 from Xu et al., 2022
whole organism hadhaa expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 , Figure 4 , Figure 5 from Xu et al., 2022
whole organism serine decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism histidine decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism sqlea expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 4 from Xu et al., 2022
whole organism isoleucine decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism asparagine decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism sc5d expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 4 from Xu et al., 2022
whole organism glutamic acid decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
whole organism pfkmb expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 5 from Xu et al., 2022
whole organism aglb expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 5 from Xu et al., 2022
whole organism ugt5a5 expression decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 4 , Figure 5 from Xu et al., 2022
whole organism valine decreased amount, abnormal	nr4a1^{xmu201/xmu201} (AB)	standard conditions	Figure 3 from Xu et al., 2022
insulin secretion involved in cellular response to glucose stimulus disrupted, abnormal	nr4a1^{xmu201/xmu201}; tud202Tg; vu513Tg	standard conditions	Figure 6 from Xu et al., 2022
pancreatic B cell decreased amount, abnormal	nr4a1^{xmu201/xmu201}; vu513Tg	standard conditions	Figure 6 from Xu et al., 2022
pancreatic B cell mCherry expression amount, ameliorated	nr4a1^{xmu201/xmu201}; ia1Tg; xmu202Tg	standard conditions	Figure 7 from Xu et al., 2022
pancreatic B cell amount, ameliorated	nr4a1^{xmu201/xmu201}; vu513Tg; xmu202Tg	standard conditions	Figure 7 from Xu et al., 2022

Citations