Genomic Feature
uob101
- ID
- ZDB-ALT-200909-1
- Name
- uob101
- Synonyms
-
- Δ73-303 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Monteiro Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 11: 3852406 - 3852639 (GRCz11) (1) Details
- Nucleotide change
- TTCACACATAGTGCTCTGATAATCGCTTTACAGTAGATGTCATTCGGGCCTGCCGGGGCCAGAGAAAATTCAGCCGGGTTTGTTGAAGACGGAAACACCCGGGAGCCTGGCTTCCTTATCGGGCCCGGGCAGATATCCGGATAGGAAACAACTGGATGGCCTTTGAACAGCGCTCTGAAAACACTTCAACCCAAAATGCAAAAGCATGGGCCAGCACACTGACTCCATGGAAAA/AGC
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 3 bp inserted / 234 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CCGATGAAATTCGTTTTTCCCCTGACCTTCATCTAATAAATTCTGCCATATTTCAGCTAAATGCATTAGACAGATCATTAATTTATAACGTTTCGATACACTGCTCCCCTTCATGCCACGAATCAAACGCTTTCAGTGGGCGGGGCGACTGCAAAAGCCGGGTCATCAATCCTCTGTTCGCTTTTTTGTCCATTGCGGATCAATTTTTCACACATAATGAGAAACATTTATAGGCGTACAGCGCAATTCCCCTGCAGTCCAACACGTATAGCGTTTGCAGTTTGTGTTCATTAACGATTTACATATTAAATTCTATTGCCTTTTTGTGCCGGATAAAACAAAATGCCGCTTTGGATAAAATGAAACAAAACGCAGACGACAACAAACACACACACACACACACATGCATTCCGATGCTTCAACTCAGTGCCAGTCGAGCATGACAAACAAGAGAGCAAAGAGTATAAATCCATTTATTTTCCAATCCCTGCCCCAGCCCC
TTCACACATAGTGCTCTGATAATCGCTTTACAGTAGATGTCATTCGGGCCTGCCGGGGCCAGAGAAAATTCAGCCGGGTTTGTTGAAGACGGAAACACCCGGGAGCCTGGCTTCCTTATCGGGCCCGGGCAGATATCCGGATAGGAAACAACTGGATGGCCTTTGAACAGCGCTCTGAAAACACTTCAACCCAAAATGCAAAAGCATGGGCCAGCACACTGACTCCATGGAAAA/AGC CCCTGTGGCCCTTTACTATGAGAACATATAGCTAGAGAAAAGCAGAAATTGCTGCTAAAAATAATAATGATCACCACAACATTCTCAACAATCACCATAATTTAATTCCTTTTTGAATATGTAACTCCAGCTGAGTATGTAAGAGTCTATTTTACAACAAGATTCCCTCAGAGACGTTTATATTTACACTCTGACGGTCACTTAGCCAAGGGAAAATTAAATTATGACACATGGCTGATAGAAAAAGACAGTCTCACTCAATTAAATCGCTTGTTGTGTCTCTAAATGAATCTCCACGATAGTATTACATCACTTTTTGAAAGGGTGACTCAATAAGAGAGTAAGGAGACAGAGGTTGAACTATAGAGTTTCAGCCACTAAAGGATAAAATAAGATTACGTTGATAGAAAAAGCTTTGGTTTTGGGAAAATATCCTTCCATATTCTTTGAAAAGTCATGTTTTTATAGGATCCCGATGCTGGAAAAGCTGTCACCCCTGC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| en.gata2a.i4uob101/uob101 | Homozygous | ♀+/- ♂+/- | 2 figures  from Dobrzycki et al., 2020 | 4 figures from Dobrzycki et al., 2020 | |
| en.gata2a.i4uob101/uob101 + MO1-gata2b | Complex | Fig. 5 from Dobrzycki et al., 2020 | Fig. 5 from Dobrzycki et al., 2020 |
1 - 2 of 2
Show
Supplemental Information
- Genotyping protocol
- None
- Mahony, C.B., Copper, L., Vrljicak, P., Noyvert, B., Constantinidou, C., Browne, S., Pan, Y., Palles, C., Ott, S., Higgs, M.R., Monteiro, R. (2023) Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency. Cell Reports. 42:112571112571
- Gioacchino, E., Koyunlar, C., Zink, J., de Looper, H., de Jong, M., Dobrzycki, T., Mahony, C.B., Hoogenboezem, R., Bosch, D., van Strien, P.M.H., van Royen, M.E., French, P.J., Bindels, E., Gussinklo, K.J., Monteiro, R., Touw, I.P., de Pater, E. (2021) Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish. Blood advances. 5:2687-2700
- Dobrzycki, T., Mahony, C.B., Krecsmarik, M., Koyunlar, C., Rispoli, R., Peulen-Zink, J., Gussinklo, K., Fedlaoui, B., de Pater, E., Patient, R., Monteiro, R. (2020) Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis. Communications biology. 3:71
1 - 3 of 3
Show