Genomic Feature
ch200
- ID
- ZDB-ALT-170412-1
- Name
- ch200
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Chuan He Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 17: 27414147 - 27414154 (GRCz11) (1) Details
- Nucleotide change
- ATTCCTGA/-
- Variant Notes
-
8 bp deletion upstream of the YTH RNA-binding domain
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
TCTTCAACACTTGACGTGCCTTGTCTAGAGGAACCTCCTGTGTGTCGCGAGAGTTGGTTACCGGCTTATTCTCATTGTTCTCCAAGCGAATGTGCCTTAGTTGGCTGTTGGGAACGTCCTTGACAAAGATCCAGCGCACATCGAAACGACCCTTCCACTTGTCCTGCGACCACACGCCTGCACAAGTGTTGTAGTCCACAGGCGAGCGCATCTCCGCCACGCCACAGAAGTGCCCACTGCCATTCACACTGAAGAGCAGGTACAGTGGCCCTTTGTTGGCTAGCGAACGGTATGCAGCGTCCAGACGCTTATTGCCATGTTCTGTGCTGCACCAGATATTGTACTTAATGGACCGGTGGATATCGTCCTCAGAGTAACTCTTGATGATGAAGACACGACCATGTTTAGGGTTCCAGTCGAAGTCCTTGGGATTGTAGTTGTTTACCATGCGCAGTTTTTCTAGAACTGGGTGGGGTTCTGCTGGCACAGTAATGCCACCC
ATTCCTGA/- ATTGGGAGGGGATTGGCCAGGTCCACCTGCTGCATCCCCAAAGCCGTTGGCACGGTTACGCGGGGGCACCCAGCGGGTTGGCTGGGAGGGTTGGGAAGCTGGTGGGCCCTGGGAGAGTTGAGGTGGAACAGCACCGGGCTGGCCACCTGGAGGAAGAGGGTGCTGGACAAGCTGTCCAGTAGGAGGAACTAGCTGTCCATTGCTGAGGGGCAACTGAGGCACCCCACCAGCAGTAGCACCTGGTTGAGGAGACGACTGATTGGGTGGCTGTCCATTAGTGGGCAGGGAAGTCTGCTGTGGGGCTGCTGGTTTAGGCATATTCCCCTTGTTGTCCCATGTCCCAATATCCATGTTATGTTTTATTGGAGGTGGTGGCAGATTTGTCCCACCAAGTCCCCCCTTAGTTTTCAATTTAGGCTGTGGTTTGGCTGGCTTGCTGGCAATGTCCGCCCAAGAAGCAGTTTTCGCAGGAGCCATGGAGGCAGGAGGCATGGTTGGAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ythdf2ch200/ch200 | Homozygous | ♀-/- ♂-/- | Fig. 3  from Kontur et al., 2020 | Fig. 2 from Kontur et al., 2020 | |
| ythdf2ch200 (AB) | Unknown | ♀-/- ♂+/+ | 2 figures from Zhao et al., 2017 | 2 figures from Zhao et al., 2017 | |
| ythdf2ch200/ch200; ythdf3ya3323/ya3323 | Complex | Fig. 4 from Kontur et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Xiao, Y., Chen, J., Yang, S., Sun, H., Xie, L., Li, J., Jing, N., Zhu, X. (2022) Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development. The EMBO journal. 42(3):e111364
- Kontur, C., Jeong, M., Cifuentes, D., Giraldez, A.J. (2020) Ythdf m6A Readers Function Redundantly during Zebrafish Development. Cell Reports. 33:108598
- Zhao, B.S., Wang, X., Beadell, A.V., Lu, Z., Shi, H., Kuuspalu, A., Ho, R.K., He, C. (2017) m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition.. Nature. 542(7642):475-478
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