Gene
ythdf2
- ID
- ZDB-GENE-040426-948
- Name
- YTH N6-methyladenosine RNA binding protein F2
- Symbol
- ythdf2 Nomenclature History
- Previous Names
-
- yth2
- zgc:56224
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables N6-methyladenosine-containing RNA reader activity. Involved in several processes, including endothelial to hematopoietic transition; negative regulation of Notch signaling pathway; and regulation of hematopoietic stem cell differentiation. Acts upstream of or within female gonad development; hematopoietic stem cell proliferation; and mRNA catabolic process. Predicted to be located in P-body and cytoplasmic stress granule. Predicted to be active in cytoplasm. Orthologous to human YTHDF2 (YTH N6-methyladenosine RNA binding protein F2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56224 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ch200 | Allele with one deletion | Unknown | Premature Stop | TALEN | |
| ihb685 | Allele with one deletion | Exon 4 | Unknown | CRISPR | |
| ihb686 | Allele with one delins | Exon 4 | Unknown | CRISPR | |
| sa1176 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36430 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ya3322 | Allele with one deletion | Exon 4 | Premature Stop | CRISPR |
1 - 6 of 6
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ythdf2 | Kontur et al., 2020 | |
| CRISPR2-ythdf2 | Kontur et al., 2020 | |
| CRISPR3-ythdf2 | Zebrafish Nomenclature Committee | |
| CRISPR4-ythdf2 | Lin et al., 2023 | |
| MO1-ythdf2 | N/A | (3) |
| TALEN1-ythdf2 | (3) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | YTH domain | YTH domain containing protein |
|---|---|---|---|---|
| UniProtKB:E7F1H9 | InterPro | 613 |
1 - 1 of 1
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ythdf2-201
(1)
|
Ensembl | 3,021 nt | ||
| mRNA |
ythdf2-203
(1)
|
Ensembl | 2,394 nt | ||
| ncRNA |
ythdf2-002
(1)
|
Ensembl | 963 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available