Genomic Feature
stl27
- ID
- ZDB-ALT-170405-2
- Name
- stl27
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Lila Solnica-Krezel lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 3: 17072854 - 17072860 (GRCz11) (1) Details
- Nucleotide change
- TGGAGCA/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 7 bp deleted in Exon 5 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TTTAATCTCGCTCAGCCACATGTGGATGGCATCATCTAAACCTGGGGTGTCCAAACTCGGTCCTGGAGGGTCAGTGTCTTGCAGATTTTAGCTTCATCCTTGCAGATGTGTTGAGGCAAATTGTTTCTAGAAAGCCTAGTAAGAGCTTGATTAGTTAGCGCAGGTGTGTCTGATTGGGGTTGGAACTAAACTTTGCTGGACACCGGCCCTCCAGGATCGTGTTTGGACATGCCTGATCTAAACTATTTTGAGTTTGTCCACTTTCAGCCACTTAATGTAACCACACATGTGGTTAAATGTATTCAGACACAAAAGACCAGCTACCCTCCACCTGAACTCTTGTTTACAGTGGTGTAAATGGTAATACCTCTCAGCTGACCACCTGTGACCATATGACTGAAAATGCATGTTATAACAATCTGAAAACTGAAAATACTAAAACTGAAACTAATATTTAGCTATTGCTTGGGTATAACCTCTTACTCATCCTCCACAGGACA
TGGAGCA/- GAAGATGAAAATGTTGGAGAATCTGCAGGATGATTTTGATTTCAACTACAAAACTCTTAAGAGTGCTGGAGGTATGACTGCATTGGAAATGTTGTTTTTTGGTCAGGGTTCCACAATATATAGTTTCAGCATCAATATTACAATGTGCATATCCACAATAGTCATATGGCAGGATGCACAGTGCCATGCAGGGATTATAGGTGAACAGGGACTACAATTTGAATTTTGTCATTTTGAAAATTTGTCATTTTGATATTAATTACAAATTTTAACCATTTTGGAATTTGTAAATTCATAATTTGTTCATTTTTTTCTGTTAATATGAGTTCAAGGCCTGTGATGCAATCAACTCTCTATATTTCTATATTCAATATCTGTATCTGACTTTCCAAAGACTTACCAAAAAATATAAAGCACAATTTTCTTTTCTCATTTTAAGGCTTTGTTTTTGTATTTATCTAGTTTATTATGCACTATACTATGTACCTTATAGATGTATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| stat3stl27/stl27 | Homozygous | Unknown | Fig. 1.  from Allanki et al., 2021 | ||
| stat3stl27/stl27 | Homozygous | ♀-/- | 7 figures from Liu et al., 2017 | 3 figures from Liu et al., 2017 | |
| stat3stl27/stl27 | Homozygous | ♀+/- ♂+/- | 2 figures from 2 publications | 2 figures from Liu et al., 2017 | |
| stat3stl27 | Unknown | ♀-/- | 4 figures from Liu et al., 2017 | Fig. 3 from Liu et al., 2017 | |
| stat3stl27/stl27 + MO1-stat3 | Complex | Fig. 3 from Liu et al., 2017 | Fig. 3 from Liu et al., 2017 | ||
| stat3stl27/stl27; s931Tg; s939Tg | Complex | Fig. 6 from Khaliq et al., 2018 | Fig. 6 from Khaliq et al., 2018 | ||
| stat3stl27/stl27; uwm37Tg | Complex | Fig. 4 from Miskolci et al., 2019 | Fig. 4 from Miskolci et al., 2019 | ||
| vangl2vu67/vu67; stat3stl27/stl27 | Complex | Fig. 4 from Liu et al., 2017 | |||
| vangl2vu67/vu67; stat3stl27/+ | Complex | Fig. 4 from Liu et al., 2017 | |||
| wnt11f2tz216/tz216; stat3stl27/stl27 | Complex | Fig. 4 from Liu et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Allanki, S., Strilic, B., Scheinberger, L., Onderwater, Y.L., Marks, A., Günther, S., Preussner, J., Kikhi, K., Looso, M., Stainier, D.Y.R., Reischauer, S. (2021) Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration. Science advances. 7:eabg6497
- Miskolci, V., Squirrell, J., Rindy, J., Vincent, W., Sauer, J.D., Gibson, A., Eliceiri, K.W., Huttenlocher, A. (2019) Distinct inflammatory and wound healing responses to complex caudal fin injuries of larval zebrafish. eLIFE. 8:
- Khaliq, M., Ko, S., Liu, Y., Wang, H., Sun, Y., Solnica-Krezel, L., Shin, D. (2018) Stat3 regulates liver progenitor cell-driven liver regeneration in zebrafish. Gene Expression. 18(3):157-170
- Liu, Y., Sepich, D.S., Solnica-Krezel, L. (2017) Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation. PLoS Genetics. 13:e1006564
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