Genomic Feature
sa29
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 5: 40732319 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Lys>Stop at position 88 (1)
- Flanking Sequence
-
- Additional Sequence
- None
Fish
Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
---|---|---|---|---|---|
isl1asa29/sa29 | Homozygous | ♀+/- ♂+/- | 8 figures ![]() | 5 figures ![]() | |
isl1asa29/+ (AB) | Heterozygous | Unknown | |||
isl1asa29 | Unknown | Unknown | |||
isl1asa29/sa29; f2Tg/+; twu26Tg/+ | Complex | Fig. 5 ![]() | Fig. 5 ![]() | ||
isl1asa29/sa29; hu10018Tg; hu11828Tg; nkuasgfp1aTg | Complex | Fig. 5 ![]() | |||
isl1asa29/sa29; ml2Tg | Complex | Fig. 7 ![]() | |||
isl1asa29/sa29; s883Tg | Complex | 2 figures ![]() | |||
isl1asa29/+; y1Tg/+ | Complex | ||||
isl1asa29/sa29 + MO3-isl2a | Complex | Fig. 4 ![]() | |||
isl1asa29/sa29; s883Tg + MO1-isl2a | Complex | Fig. 2 ![]() |
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Supplemental Information
- Genotyping protocol
- None
- Abu Nahia, K., Migdał, M., Quinn, T.A., Poon, K.L., Łapiński, M., Sulej, A., Liu, J., Mondal, S.S., Pawlak, M., Bugajski, Ł., Piwocka, K., Brand, T., Kohl, P., Korzh, V., Winata, C. (2021) Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region. Cellular and molecular life sciences : CMLS. 78(19-20):6669-6687
- Jing, Y., Ren, Y., Witzel, H.R., Dobreva, G. (2021) A BMP4-p38 MAPK signaling axis controls ISL1 protein stability and activity during cardiogenesis. Stem Cell Reports. 16(8):1894-1905
- Burkhard, S.B., Bakkers, J. (2018) Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate. eLIFE. 7
- Guerra, A., Germano, R.F., Stone, O., Arnaout, R., Guenther, S., Ahuja, S., Uribe, V., Vanhollebeke, B., Stainier, D.Y., Reischauer, S. (2018) Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. eLIFE. 7
- Witzel, H.R., Cheedipudi, S., Gao, R., Stainier, D.Y., Dobreva, G.D. (2017) Isl2b regulates anterior second heart field development in zebrafish. Scientific Reports. 7:41043
- Caputo, L., Witzel, H.R., Kolovos, P., Cheedipudi, S., Looso, M., Mylona, A., van IJcken, W.F., Laugwitz, K.L., Evans, S.M., Braun, T., Soler, E., Grosveld, F., Dobreva, G. (2015) The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors. Cell Stem Cell. 17:287-99
- Chetaille, P., Preuss, C., Burkhard, S., Côté, J.M., Houde, C., Castilloux, J., Piché, J., Gosset, N., Leclerc, S., Wünnemann, F., Thibeault, M., Gagnon, C., Galli, A., Tuck, E., Hickson, G.R., Amine, N.E., Boufaied, I., Lemyre, E., de Santa Barbara, P., Faure, S., Jonzon, A., Cameron, M., Dietz, H.C., Gallo-McFarlane, E., Benson, D.W., Moreau, C., Labuda, D., FORGE Canada Consortium, Zhan, S.H., Shen, Y., Jomphe, M., Jones, S.J., Bakkers, J., Andelfinger, G. (2014) Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Nature Genetics. 46(11):1245-9
- Gu, A., Ji, G., Yan, L., and Zhou, Y. (2013) The 8-oxoguanine DNA glycosylase 1 (ogg1) decreases the vulnerability of the developing brain to DNA damage. DNA repair. 12(12):1094-104
- Wilfinger, A., Arkhipova, V., and Meyer, D. (2013) Cell type and tissue specific function of islet genes in zebrafish pancreas development. Developmental Biology. 378(1):25-37
- Tessadori, F., van Weerd, J.H., Burkhard, S.B., Verkerk, A.O., de Pater, E., Boukens, B.J., Vink, A., Christoffels, V.M., and Bakkers, J. (2012) Identification and functional characterization of cardiac pacemaker cells in zebrafish. PLoS One. 7(10):e47644
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