Genomic Feature
jj410
- ID
- ZDB-ALT-070426-3
- Name
- jj410
- Synonyms
-
- ale ucho (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Malicki Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| Mutation in lmx1b (ENSDARG00000068365) that introduces a premature termination ... | ZFIN Staff |
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 8: 33281069 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
ATTTCACACAATTGTTACTTATTATACATTTATACCTCACAATAGCTACAGTAATAGTACAGTTTCTATCCAAAGATGCAAATTAGATTCATGCGCAAAACTTGAAATCCCACAAAACATTTTGGAAATATAACACCGTTTTTCTTGTGGCGACCCCTGATGAATAAAGGGACTAAGCCGAAGGAAAATGAATGAATGTATGAAGTTTATTCTACTCAGATGCCTGGATAAGTTGTTATGCGAATCTTGGTGTTTTTCCATTAAGAATGTTTTTATGCAATGTCCCAAATTCGCTTACAAAAGGGTGGATTGAAACATAGCTCAAACCATTTTTATTCTTATTGACTCATGATCTGACATCCATATAAAAACAAGAGATGGAGGAAGCTGATATCCGGAGGAACGCACCTTCCGGCAGGGTTTGGAAGACACCTCGAACGACGCCTTGAAGGCTCGTCTCTGCTGTGTGGTGAGGATGGTACGTGGTCTCTTGGGTCTTC
A/T AGGGTCTTTCCCATCATCTCCCTTCCCGGTGCCTCCCGAGCCTTTCTCCGGCTTGATATCCAGCTCCTCATCTTCGCTTTTCTCTGAAAAGGAATCCATCATTCATCAAAATCAGTAAAAAAAAAAATCTGCAAAGTTTTTAGACACTGATAAATAGGTGTTTTTGTTCTTTTCAATTTTAGGGTATTCAGTCTCAGCGCATCCATAACGAAAGGAGACACATGTGGTTTTAATACTTTTGTTATCAATTTATTAGTGCACGAGTGGGCCACATCCACTGCAACCCTGACTGTGAAGTATGTGAATTTGTCATTGGACTGGACGTTGTGTCATTTAAAATTAATAGCGCACGGCTTTGGCTGTTTTGCACTATATAAATCTTTGATAAGAATCCAACACACAGCAAATGCGACGTTTTGGGAAGGTATGAAGGCAGAGTACATATGGGAAATGAGTTCTAATATCCAGGGGAAGTGAAACAGATAGCGAAACCGCAAATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| lmx1bbjj410/jj410 | Homozygous | ♀+/- ♂+/- | 5 figures  from 2 publications | 4 figures from Hilinski et al., 2016 | |
| lmx1bbjj410/jj410 (AB) | Homozygous | ♀+/- ♂+/- | 5 figures from 2 publications | 2 figures from 2 publications | |
| lmx1bbjj410/+ | Heterozygous | Unknown | Fig. 4 from Hilinski et al., 2016 | ||
| lmx1bbjj410/+ (AB) | Heterozygous | Unknown | |||
| lmx1bbjj410/jj410; hm30Tg | Complex | Fig. 3 from Swinburne et al., 2018 | |||
| lmx1bbjj410/jj410; nns14Tg; su1Tg | Complex | Fig. 7 from Hilinski et al., 2016 | Fig. 7 from Hilinski et al., 2016 | ||
| lmx1bbjj410/jj410; su1Tg | Complex | Fig. 7 from Hilinski et al., 2016 | 2 figures from Hilinski et al., 2016 | ||
| lmx1bbjj410/jj410; lmx1bamw80/mw80 | Complex | Fig. 4 from Hilinski et al., 2016 | Fig. 4 from Hilinski et al., 2016 | ||
| lmx1bbjj410/+; lmx1bamw80/+ | Complex | Fig. 4 from Hilinski et al., 2016 | Fig. 4 from Hilinski et al., 2016 |
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Supplemental Information
- Genotyping protocol
- None
- Mori, Y., Smith, S., Wang, J., Eliora, N., Heikes, K.L., Munjal, A. (2024) Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis. Development (Cambridge, England). 152(1):
- Swinburne, I.A., Mosaliganti, K.R., Upadhyayula, S., Liu, T.L., Hildebrand, D.G.C., Tsai, T.Y., Chen, A., Al-Obeidi, E., Fass, A.K., Malhotra, S., Engert, F., Lichtman, J.W., Kirchausen, T., Betzig, E., Megason, S.G. (2018) Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure. eLIFE. 7
- Hilinski, W.C., Bostrom, J.R., England, S.J., Juárez-Morales, J.L., de Jager, S., Armant, O., Legradi, J., Strähle, U., Link, B.A., Lewis, K.E. (2016) Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. Neural Development. 11:16
- Obholzer, N., Swinburne, I.A., Schwab, E., Nechiporuk, A.V., Nicolson, T., and Megason, S.G. (2012) Rapid positional cloning of zebrafish mutations by linkage and homozygosity mapping using whole-genome sequencing. Development (Cambridge, England). 139(22):4280-4290
- Schibler, A., and Malicki, J. (2007) A screen for genetic defects of the zebrafish ear. Mechanisms of Development. 124(7-8):592-604
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