Genomic Feature
hi2151Tg
- ID
- ZDB-ALT-040915-12
- Name
- hi2151Tg
- Synonyms
-
- hi2151 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- embryos treated with DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the minus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 13: 8841167 - 8841168 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Exon 2 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| epcamhi2151Tg/hi2151Tg | Homozygous | ♀+/- ♂+/- | Fig 1  from Hatzold et al., 2023 | ||
| epcamhi2151Tg/hi2151Tg | Homozygous | ♀-/- | 6 figures from Slanchev et al., 2009 | ||
| epcamhi2151Tg/hi2151Tg | Homozygous | Unknown | 2 figures from 2 publications | Fig. 1 from Lu et al., 2013 | |
| epcamhi2151Tg | Unknown | Unknown | Fig. for (hi2151) from Phenotype Annotation (1994-2006) | ||
| epcamhi2151Tg; as3Tg | Complex | 5 figures from Lu et al., 2013 | Fig. 2 from Lu et al., 2013 | ||
| epcamhi2151Tg; s854Tg | Complex | Fig. 1 from Lu et al., 2013 | Fig. 6 from Lu et al., 2013 | ||
| epcamhi2151Tg/hi2151Tg + MO3-cdh1 | Complex | 2 figures from Slanchev et al., 2009 | |||
| epcamhi2151Tg; as3Tg + MO1-dkk2 | Complex | Fig. 4 from Lu et al., 2013 | |||
| epcamhi2151Tg/hi2151Tg + MO1-st14a | Complex | Fig 1 from Hatzold et al., 2023 |
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Supplemental Information
- Genotyping protocol
- None
- Lee, S., Memon, A., Chae, S.C., Shin, D., Choi, T.Y. (2024) Epcam regulates intrahepatic bile duct reconstruction in zebrafish, providing a potential model for primary cholangitis model. Biochemical and Biophysical Research Communications. 696:149512149512
- Hatzold, J., Nett, V., Brantsch, S., Zhang, J.L., Armistead, J., Wessendorf, H., Stephens, R., Humbert, P.O., Iden, S., Hammerschmidt, M. (2023) Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects. PLoS Genetics. 19:e1010873e1010873
- Kuechlin, S., Schoels, M., Slanchev, K., Lassmann, S., Walz, G., Yakulov, T.A. (2017) EpCAM controls morphogenetic programs during zebrafish pronephros development. Biochemical and Biophysical Research Communications. 487(2):209-215
- Lu, H., Ma, J., Yang, Y., Shi, W., and Luo, L. (2013) EpCAM Is an Endoderm-Specific Wnt Derepressor that Licenses Hepatic Development. Developmental Cell. 24(5):543-553
- Slanchev, K., Carney, T.J., Stemmler, M.P., Koschorz, B., Amsterdam, A., Schwarz, H., and Hammerschmidt, M. (2009) The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. PLoS Genetics. 5(7):e1000563
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
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