Genomic Feature
w21
- ID
- ZDB-ALT-030903-2
- Name
- w21
- Synonyms
-
- nof (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- ENU
- Lab of Origin
- Hurley Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 8: 25233008 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T at position 154 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Gln>Stop at position 52 (1)
- Flanking Sequence
-
TGAACATCATAACATGCTTTTTAGAGAATCATTTTCACACTAATAATTGTTCTGTTTGTTTTAGAGCAGTCCTGCAGACCTGTGCAGATGGCGATCCAAAGTTGATTGACAGCATCTCCATGCCCCTGATGATGGCCAGAGCAGACTGCAGGATGTTGCCAAAAATAATAGATCGAAACTCCATTTGTTCTTCTTTTGTATAACCACCTTGATGGAGAATCCTTGGACAGGAACAAGAGGGGTTTTTATTAATGATTTGAAGATAAAGGACAGGCTCCTCATTCACTACCACCTAGTGATAACAGTTTAGGGTCTCAACTCTACTGTAGGTAAGCGCTGGTATTCCCCAAATGCACACTAAATGTTAAGGATTAATTCAGTTAGAATGCAAGAAACCTAAATCTCAATTCAAGAGCTTACACAGCTTGTCTACAAAGATACAAATTGTCATATCTGAGCATGTGTTTTGTATATCGCATGTGTTTCAACTCACTTCATCT
G/A TTTTACAATGGTGCTCTTCCCTGATTCACCAGCACCTATAAAACAAAGGGGAAAAAACATGATGTAGAGCAAATAAAGGACAAACGAGTCCTCAAACGCTTTTAAACCAAACATCACACAAAGTTTTGGCACGATGAACTCCATCTGTAACTTTTAACTTCATTCGAAGGTCTTTGAACAAACCACATTGAGCTGAATCTTAGTCCCTTGGTTACATATTCCATTGTGACATTGATGTATCACTTCATACAGATAACATAATGCCTGAATTTTTCCTGAATTTAAACCATTTGTTTTCCTCTCTATGGATATTGATTTTAATAACAAGGTCAATGTTAAGCTGTAGATAACCTGTCAAGAAAAACTCATAGATTGCCATTGATGGGCAGGTCAGAGGAAGGCTTATGAGCCTGCTTATAAAGTGACCCAATTGGATTTGTGTTAGGGAAAGCTTCTCAGAAGATCACTGACACTTTGATTCGCCTTTGAGCTTCAGTCAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| gnat2w21/w21 | Homozygous | ♀+/- ♂+/- | |||
| gnat2w21/w21 (AB) | Homozygous | Unknown | Fig. for (w21) from Phenotype Annotation (1994-2006) | text only from Brockerhoff et al., 2003 | |
| gnat2w21/+ (AB) | Heterozygous | Unknown | |||
| gnat2w21/+; mpv17a9/+ (AB) | Complex |
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Supplemental Information
- Genotyping protocol
- None
- Venkatraman, P., Mills-Henry, I., Padmanabhan, K.R., Pascuzzi, P., Hassan, M., Zhang, J., Zhang, X., Ma, P., Pang, C.P., Dowling, J.E., Zhang, M., Leung, Y.F. (2020) Rods Contribute to Visual Behavior in Larval Zebrafish. Investigative ophthalmology & visual science. 61:11
- Moyano, M., Porteros, A., and Dowling, J.E. (2013) The effects of nicotine on cone and rod b-wave responses in larval zebrafish. Visual neuroscience. 28:1-5
- Kennedy, B.N., Alvarez, Y., Brockerhoff, S.E., Stearns, G.W., Sapetto-Rebow, B., Taylor, M.R., and Hurley, J.B. (2007) Identification of a Zebrafish Cone Photoreceptor-Specific Promoter and Genetic Rescue of Achromatopsia in the nof Mutant. Investigative ophthalmology & visual science. 48(2):522-529
- Cilluffo, M.C., Matthews, H.R., Brockerhoff, S.E., and Fain, G.L. (2004) Light-induced Ca2+ release in the visible cones of the zebrafish. Visual neuroscience. 21(4):599-609
- Tsujikawa, M., and Malicki, J. (2004) Genetics of photoreceptor development and function in zebrafish. The International journal of developmental biology. 48(8-9):925-934
- Brockerhoff, S.E., Rieke, F., Matthews, H.R., Taylor, M.R., Kennedy, B., Ankoudinova, I., Niemi, G.A., Tucker, C.L., Xiao, M., Cilluffo, M.C., Fain, G.L., and Hurley, J.B. (2003) Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(2):470-480
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