ZFIN Person: Peri, Francesca

ZFIN ID: ZDB-PERS-020719-19

ZFIN ID: ZDB-PERS-020719-19

Peri, Francesca

Email:	francesca.peri@uzh.ch
URL:	http://www.imls.uzh.ch/en/research/peri.html
Affiliation:	Peri Lab
Address:	Department of Molecular Life Sciences University of Zurich Winterthurerstrasse 190 CH-8057 Zurich
Country:	Switzerland
Phone:	+41 44 635 31 90
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Short CV
01.01.2018 Full Professor, IMLS, UZH, Switzerland
2008-2017 Group Leader at EMBL, Heidelberg, Germany
2002-2007 Postdoctoral research at the Max Planck Institute for Developmental Biology, Tübingen, Germany
1997 PhD, University of Cologne, Germany
Studies in Genetics, Molecular Biology and Biochemistry, University of Padua, Italy
Biography
Francesca was born in Mestre, near Venice (Italy). She studied Biology, and she graduated from the University of Padova (Italy). For her PhD, Francesca moved to Cologne in Germany where she worked with Siegfried Roth on the establishment of the dorsoventral and anteroposterior polarity in Drosophila. After obtaining her PhD in 2001, she joined the lab of Christiane Nuesslein-Volhard at the Max-Plank Institute for Developmental Biology in Tüningen (Germany). During her postdoc, she started working on how microglia, the brain immune cells, engulf and digest dying neurons using zebrafish. In 2008 Francesca became a group leader at the European Molecular Biology Laboratory (EMBL) in Heidelberg. She received an ERC Starting grant in 2010 and her lab continued exploiting the massive imaging potential of the transparent fish embryo to investigate microglia and their interaction with neurons. Since 2018 Francesca is a Full Professor at the University of Zürich.
When she is not in the lab, Francesca enjoys spending time with her family. She loves reading, cooking and travelling.

PUBLICATIONS

Möller, K., Brambach, M., Villani, A., Gallo, E., Gilmour, D., Peri, F. (2022) A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo. eLIFE. 11:

de Medeiros, G., Kromm, D., Balazs, B., Norlin, N., Günther, S., Izquierdo, E., Ronchi, P., Komoto, S., Krzic, U., Schwab, Y., Peri, F., de Renzis, S., Leptin, M., Rauzi, M., Hufnagel, L. (2020) Cell and tissue manipulation with ultrashort infrared laser pulses in light-sheet microscopy. Scientific Reports. 10:1942

Geirsdottir, L., David, E., Keren-Shaul, H., Weiner, A., Bohlen, S.C., Neuber, J., Balic, A., Giladi, A., Sheban, F., Dutertre, C.A., Pfeifle, C., Peri, F., Raffo-Romero, A., Vizioli, J., Matiasek, K., Scheiwe, C., Meckel, S., Mätz-Rensing, K., van der Meer, F., Thormodsson, F.R., Stadelmann, C., Zilkha, N., Kimchi, T., Ginhoux, F., Ulitsky, I., Erny, D., Amit, I., Prinz, M. (2019) Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program. Cell. 179:1609-1622.e16

Herzog, C., Pons Garcia, L., Keatinge, M., Greenald, D., Moritz, C., Peri, F., Herrgen, L. (2019) Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo. Development (Cambridge, England). 146(9):

Villani, A., Benjaminsen, J., Moritz, C., Henke, K., Hartmann, J., Norlin, N., Richter, K., Schieber, N.L., Franke, T., Schwab, Y., Peri, F. (2019) Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment. Developmental Cell. 49(1):77-88.e7

Casano, A.M., Albert, M., Peri, F. (2016) Developmental Apoptosis Mediates Entry and Positioning of Microglia in the Zebrafish Brain. Cell Reports. 16(4):897-906

Peri, F., Powell, K. (2015) Francesca Peri: Micromanaging the lives of microglia. The Journal of cell biology. 211:208-9

Rossi, F., Casano, A.M., Henke, K., Richter, K., Peri, F. (2015) The SLC7A7 Transporter Identifies Microglial Precursors prior to Entry into the Brain. Cell Reports. 11(7):1008-17

Moritz, C., Berardi, F., Abate, C., Peri, F. (2015) Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries. Neuroscience letters. 591:13-8

Mazaheri, F., Breus, O., Durdu, S., Haas, P., Wittbrodt, J., Gilmour, D., Peri, F. (2014) Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia. Nature communications. 5:4046

Bitomsky, N., Conrad, E., Moritz, C., Polonio-Vallon, T., Sombroek, D., Schultheiss, K., Glas, C., Greiner, V., Herbel, C., Mantovani, F., Del Sal, G., Peri, F., and Hofmann, T.G. (2013) Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death. Proceedings of the National Academy of Sciences of the United States of America. 110(45):E4203-4212

Sieger, D., and Peri, F. (2013) Animal models for studying microglia: the first, the popular, and the new.. Glia. 61(1):3-9

Sieger, D., Moritz, C., Ziegenhals, T., Prykhozhij, S., and Peri, F. (2012) Long-Range Ca(2+) Waves Transmit Brain-Damage Signals to Microglia. Developmental Cell. 22(6):1138-1148

Fantin, A., Vieira, J.M., Gestri, G., Denti, L., Schwarz, Q., Prykhozhij, S., Peri, F., Wilson, S.W., and Ruhrberg, C. (2010) Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood. 116(5):829-840

Peri, F., and Nüsslein-Volhard, C. (2008) Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo. Cell. 133(5):916-927

NON-ZEBRAFISH PUBLICATIONS