ZFIN Lab: Rodney Stewart Lab

ZFIN ID: ZDB-LAB-150518-1

Rodney Stewart Lab

PI/Director:	Stewart, Rodney A.
Contact Person:	Modzelewska, Kate
Email:	Kate.Modzelewska@hci.utah.edu
URL:
Address:	University of Utah, Huntsman Cancer Institute, HCI 3270, Salt Lake City, Utah 84112
Country:	United States
Phone:	801-587-4048
Fax:	801-587-9415
Line Designation:	zd

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 9 genomic features

STATEMENT OF RESEARCH INTERESTS

The Stewart Lab’s primary
interests focus on embryonic mechanisms altered in congenital diseases and
cancers of the neural crest, such as neuroblastoma and melanoma.

LAB MEMBERS

Morrison, Monique Post-Doc	Boer, Elena Graduate Student	Jimenez, Laura Graduate Student
Sorrells, Shelly Graduate Student	Howell, Elizabeth Research Staff	Khuu, Scott Research Staff
Truong, Harold Research Staff	Edwards, Teri Fish Facility Staff	Modzelewska, Kate Administrative Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Gopal, U., Monroe, J.D., Marudamuthu, A.S., Begum, S., Walters, B.J., Stewart, R.A., Washington, C.W., Gibert, Y., Zachariah, M.A. (2023) Development of a Triple-Negative Breast Cancer Leptomeningeal Disease Model in Zebrafish. Cells. 12(7):

Casey, M.J., Call, A.M., Thorpe, A.V., Jette, C.A., Engel, M.E., Stewart, R.A. (2022) The scaffolding function of LSD1/KDM1A reinforces a negative feedback loop to repress stem cell gene expression during primitive hematopoiesis. iScience. 26:105737105737

Casey, M.J., Stewart, R.A. (2020) Pediatric Cancer Models in Zebrafish. Trends in cancer. 6:407-418

Sorrells, S., Nik, S., Casey, M., Cameron, R.C., Truong, H., Toruno, C., Gulfo, M., Lowe, A., Jette, C., Stewart, R.A., Bowman, T.V. (2018) Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis. Disease models & mechanisms. 11(2)

Casey, M.J., Stewart, R.A. (2017) Zebrafish as a model to study neuroblastoma development. Cell and tissue research. 372(2):223-232

Boer, E.F., Jette, C.A., Stewart, R.A. (2016) Neural Crest Migration and Survival Are Susceptible to Morpholino-Induced Artifacts. PLoS One. 11:e0167278

Modzelewska, K., Boer, E.F., Mosbruger, T.L., Picard, D., Anderson, D., Miles, R.R., Kroll, M., Oslund, W., Pysher, T.J., Schiffman, J.D., Jensen, R., Jette, C.A., Huang, A., Stewart, R.A. (2016) MEK Inhibitors Reverse Growth of Embryonal Brain Tumors Derived from Oligoneural Precursor Cells. Cell Reports. 17:1255-1264

Jimenez, L., Wang, J., Morrison, M.A., Whatcott, C., Soh, K.K., Warner, S., Bearss, D., Jette, C.A., Stewart, R.A. (2016) Phenotypic chemical screening using zebrafish neural crest reporters identifies retinoid acid as an inhibitor of epithelial morphogenesis. Disease models & mechanisms. 9(4):389-400

Morrison, M.A., Zimmerman, M.W., Look, A.T., Stewart, R.A. (2016) Studying the peripheral sympathetic nervous system and neuroblastoma in zebrafish. Methods in cell biology. 134:97-138

Boer, E.F., Howell, E.D., Schilling, T.F., Jette, C.A., Stewart, R.A. (2015) Fascin1-Dependent Filopodia are Required for Directional Migration of a Subset of Neural Crest Cells. PLoS Genetics. 11:e1004946

Toruno, C., Carbonneau, S., Stewart, R.A., and Jette, C. (2014) Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis. PLoS One. 9(2):e88151

Sorrells, S., Toruno, C., Stewart, R.A., and Jette, C. (2013) Analysis of apoptosis in zebrafish embryos by whole-mount immunofluorescence to detect activated Caspase 3. Journal of visualized experiments : JoVE. (82):e51060

Pei, D., Luther, W., Wang, W., Paw, B.H., Stewart, R.A., and George, R.E. (2013) Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models. PLoS Genetics. 9(6):e1003533

Zhu, S., Lee, J.S., Guo, F., Shin, J., Perez-Atayde, A.R., Kutok, J.L., Rodig, S.J., Neuberg, D.S., Helman, D., Feng, H., Stewart, R.A., Wang, W., George, R.E., Kanki, J.P., and Look, A.T. (2012) Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis. Cancer Cell. 21(3):362-373

Sorrells, S., Carbonneau, S., Harrington, E., Chen, A.T., Hast, B., Milash, B., Pyati, U., Major, M.B., Zhou, Y., Zon, L.I., Stewart, R.A., Look, A.T., and Jette, C. (2012) Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53. PLoS Genetics. 8(8):e1002922

Bolli, N., Payne, E.M., Rhodes, J., Gjini, E., Johnston, A.B., Guo, F., Lee, J.S., Stewart, R.A., Kanki, J.P., Chen, A.T., Zhou, Y., Zon, L.I., and Look, A.T. (2011) cpsf1 is required for definitive HSC survival in zebrafish. Blood. 117(15):3996-4007

Murphy, D.A., Diaz, B., Bromann, P.A., Tsai, J.H., Kawakami, Y., Maurer, J., Stewart, R.A., Izpisúa-Belmonte, J.C., and Courtneidge, S.A. (2011) A Src-Tks5 Pathway Is Required for Neural Crest Cell Migration during Embryonic Development. PLoS One. 6(7):e22499

Stewart, R.A., Sanda, T., Widlund, H.R., Zhu, S., Swanson, K.D., Hurley, A.D., Bentires-Alj, M., Fisher, D.E., Kontaridis, M.I., Look, A.T., and Neel, B.G. (2010) Phosphatase-Dependent and -Independent Functions of Shp2 in Neural Crest Cells Underlie LEOPARD Syndrome Pathogenesis. Developmental Cell. 18(5):750-762

Stewart, R.A., Lee, J.S., Lachnit, M., Look, A.T., Kanki, J.P., and Henion, P.D. (2010) Chapter 5 - Studying peripheral sympathetic nervous system development and neuroblastoma in zebrafish. Methods in cell biology. 100:127-152

Jette, C.A., Flanagan, A.M., Ryan, J., Pyati, U.J., Carbonneau, S., Stewart, R.A., Langenau, D.M., Look, A.T., and Letai, A. (2008) BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals. Cell death and differentiation. 15(6):1063-1072

Smolen, G.A., Schott, B.J., Stewart, R.A., Diederichs, S., Muir, B., Provencher, H.L., Look, A.T., Sgroi, D.C., Peterson, R.T., and Haber, D.A. (2007) A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. Genes & Development. 21(17):2131-2136

Montero-Balaguer, M., Lang, M.R., Sachdev, S.W., Knappmeyer, C., Stewart, R.A., De La Guardia, A., Hatzopoulos, A.K., and Knapik, E.W. (2006) The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(12):3199-3212

Stewart, R.A., Arduini, B.L., Berghmans, S., George, R.E., Kanki, J.P., Henion, P.D., and Look, A.T. (2006) Zebrafish foxd3 is selectively required for neural crest specification, migration and survival. Developmental Biology. 292(1):174-188

Berghmans, S., Jette, C., Langenau, D., Hsu, K., Stewart, R., Look, T., and Kanki, J.P. (2005) Making waves in cancer research: new models in the zebrafish. Biotechniques. 39(2):227-237

Stewart, R.A., Look, A.T., Kanki, J.P., and Henion, P.D. (2004) Development of the peripheral sympathetic nervous system in zebrafish. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:237-260