ZFIN Lab: Betsholtz Lab

ZFIN ID: ZDB-LAB-120613-1

Betsholtz Lab

PI/Director:	Betsholtz, Christer
Contact Person:	Ando, Koji
Email:	kando.nieve12@gmail.com
URL:	http://www.igp.uu.se/research/vascular-biology/christer-betsholtz/
Address:	Rudbeck Laboratory, 751 85 Uppsala
Country:	Sweden
Phone:	+46 (0) 18 471 4816
Fax:
Line Designation:	uu

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 2 genomic features

STATEMENT OF RESEARCH INTERESTS

Angiogenesis and vascular permeability regulation
Endothelial cells and pericytes
Blood-brain barrier
Kidney glomerulus development, function and disease
Podocytes, their gene expression and transcriptional regulation

LAB MEMBERS

Ebarasi, Lwaki Post-Doc	Gaengel, Konstantin Post-Doc	Raschperger, Elisabeth Post-Doc
Ando, Koji

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Sá da Bandeira, D., Kilpatrick, A.M., Marques, M., Gomez-Salazar, M., Ventura, T., Gonzalez, Z.N., Stefancova, D., Rossi, F., Vermeren, M., Vink, C.S., Beltran, M., Henderson, N.C., Jung, B., van der Linden, R., van de Werken, H.J.G., van Ijcken, W.F.J., Betsholtz, C., Forbes, S.J., Cuervo, H., Crisan, M. (2022) PDGFRβ⁺ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny. Cell Reports. 40:111114

Ando, K., Tong, L., Peng, D., Vázquez-Liébanas, E., Chiyoda, H., He, L., Liu, J., Kawakami, K., Mochizuki, N., Fukuhara, S., Grutzendler, J., Betsholtz, C. (2022) KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling. Developmental Cell. 57(11):1383-1399.e7

Peng, D., Ando, K., Hußmann, M., Gloger, M., Skoczylas, R., Mochizuki, N., Betsholtz, C., Fukuhara, S., Schulte-Merker, S., Lawson, N.D., Koltowska, K. (2022) Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells. eLIFE. 11

Nishimura, Y., Ishii, T., Ando, K., Yuge, S., Nakajima, H., Zhou, W., Mochizuki, N., Fukuhara, S. (2022) Blood Flow Regulates Glomerular Capillary Formation in Zebrafish Pronephros. Kidney360. 3:700-713

Ando, K., Ishii, T., Fukuhara, S. (2021) Zebrafish Vascular Mural Cell Biology: Recent Advances, Development, and Functions. Life (Basel, Switzerland). 11(10):

Ando, K., Shih, Y.H., Ebarasi, L., Grosse, A., Portman, D., Chiba, A., Mattonet, K., Gerri, C., Stainier, D.Y.R., Mochizuki, N., Fukuhara, S., Betsholtz, C., Lawson, N.D. (2021) Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development. Developmental Biology. 479:11-22

Rho, S.S., Oguri-Nakamura, E., Ando, K., Yamamoto, K., Takagi, Y., Fukuhara, S. (2021) Protocol for analysis of integrin-mediated cell adhesion of lateral plate mesoderm cells isolated from zebrafish embryos. STAR protocols. 2:100428

Wang, G., Muhl, L., Padberg, Y., Dupont, L., Peterson-Maduro, J., Stehling, M., le Noble, F., Colige, A., Betsholtz, C., Schulte-Merker, S., van Impel, A. (2020) Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis. Nature communications. 11:2724

Ando, K., Wang, W., Peng, D., Chiba, A., Lagendijk, A., Barske, L., Crump, J.G., Stainier, D.Y.R., Lendahl, U., Koltowska, K., Hogan, B.M., Fukuhara, S., Mochizuki, N., Betsholtz, C. (2019) Peri-arterial specification of vascular mural cells from naïve mesenchyme requires Notch signaling. Development (Cambridge, England). 146(2):

Kotini, M.P., Mäe, M.A., Belting, H.G., Betsholtz, C., Affolter, M. (2018) Sprouting and anastomosis in the Drosophila trachea and the vertebrate vasculature: Similarities and differences in cell behaviour. Vascular Pharmacology. 112:8-16

Vanlandewijck, M., He, L., Mäe, M.A., Andrae, J., Ando, K., Del Gaudio, F., Nahar, K., Lebouvier, T., Laviña, B., Gouveia, L., Sun, Y., Raschperger, E., Räsänen, M., Zarb, Y., Mochizuki, N., Keller, A., Lendahl, U., Betsholtz, C. (2018) A molecular atlas of cell types and zonation in the brain vasculature. Nature. 554:475480475-480

Perisic, L., Rodriguez, P.Q., Hultenby, K., Sun, Y., Lal, M., Betsholtz, C., Uhlén, M., Wernerson, A., Hedin, U., Pikkarainen, T., Tryggvason, K., Patrakka, J. (2015) Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin. PLoS One. 10:e0122067

Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108

Ebarasi, L., Ashraf, S., Bierzynska, A., Gee, H.Y., McCarthy, H.J., Lovric, S., Sadowski, C.E., Pabst, W., Vega-Warner, V., Fang, H., Koziell, A., Simpson, M.A., Dursun, I., Serdaroglu, E., Levy, S., Saleem, M.A., Hildebrandt, F., Majumdar, A. (2015) Defects of CRB2 Cause Steroid-Resistant Nephrotic Syndrome. American journal of human genetics. 96(1):153-61

He, B., Ebarasi, L., Zhao, Z., Guo, J., Ojala, J.R., Hultenby, K., De Val, S., Betsholtz, C., Tryggvason, K. (2014) Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes. Journal of the American Society of Nephrology : JASN. 25(12):2764-77

Haas, U., Raschperger, E., Hamberg, M., Samuelsson, B., Tryggvason, K., and Haeggström, J.Z. (2011) Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 108(51):20479-84

Nishibori, Y., Katayama, K., Parikka, M., Oddsson, A., Nukui, M., Hultenby, K., Wernerson, A., He, B., Ebarasi, L., Raschperger, E., Norlin, J., Uhlén, M., Patrakka, J., Betsholtz, C., and Tryggvason, K. (2011) Glcci1 Deficiency Leads to Proteinuria. Journal of the American Society of Nephrology : JASN. 22(11):2037-46

He, B., Ebarasi, L., Hultenby, K., Tryggvason, K., and Betsholtz, C. (2011) Podocin-Green Fluorescence Protein Allows Visualization and Functional Analysis of Podocytes. Journal of the American Society of Nephrology : JASN. 22(6):1019-1023

Raschperger, E., Neve, E.P., Wernerson, A., Hultenby, K., Pettersson, R.F., and Majumdar, A. (2008) The coxsackie and adenovirus receptor (CAR) is required for renal epithelial differentiation within the zebrafish pronephros. Developmental Biology. 313(1):455-464